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Construction and Characterization of a Novel Vocal Fold Bioreactor
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A morphological classification for vocal fold leukoplakia.

Min Chen1, Changjiang Li1, Yue Yang1

  • 1Fudan University, Eye, Ear, Nose, and Throat Hospital, Department of Otolaryngology-Head and Neck Surgery, Shanghai, China; Shanghai Key Clinical, Disciplines of Otorhinolaryngology, Shanghai, China.

Brazilian Journal of Otorhinolaryngology
|September 1, 2018
PubMed
Summary
This summary is machine-generated.

A new morphological classification for vocal fold leukoplakia shows good inter-observer agreement and correlates with pathological grades. This classification, along with patient age and lesion size, aids in risk stratification for vocal fold leukoplakia.

Keywords:
DisplasiaDysplasiaLeucoplasiaLeukoplakiaMorfológicoMorphologicalPathologicalPatológicoPrega vocalVocal fold

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Area of Science:

  • Otolaryngology
  • Pathology
  • Medical Diagnostics

Background:

  • Vocal fold leukoplakia lacks a reliable method for distinguishing benign from malignant lesions.
  • Accurate diagnosis is crucial for appropriate patient management and treatment planning.

Purpose of the Study:

  • To assess the reliability of a novel morphological classification system for vocal fold leukoplakia.
  • To determine the correlation between different morphological types and their associated pathological grades.

Main Methods:

  • Retrospective review of 375 vocal fold leukoplakia cases (2009-2015).
  • Classification into flat/smooth, elevated/smooth, and rough types by two independent observers.
  • Analysis of inter-observer reliability and correlation with histopathological findings.

Main Results:

  • The morphological classification achieved 78.7% inter-observer agreement (κ=0.615).
  • Morphological types significantly correlated with pathological grades (p<0.001 for both observers).
  • Age, lesion size, and morphology were significant predictors differentiating low-risk from high-risk groups (AUC=0.863).

Conclusions:

  • The proposed morphological classification is reliable and correlates with the severity of vocal fold leukoplakia.
  • This classification, combined with clinical factors, can aid in risk stratification and guide treatment decisions.