Related Experiment Video
Updated: Aug 17, 2026

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
Published on: July 17, 2014
Hepatitis A infection in New Zealand children
Insights
Hepatitis A virus (HAV) infection prevalence was 15.4% in New Zealand youth (0-21 years) in 1978-79. Higher rates were found in Māori children and those in the northern North Island.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Hepatitis A virus (HAV) infection is a significant public health concern.
- Understanding the prevalence and risk factors of HAV infection is crucial for targeted prevention strategies.
Purpose of the Study:
- To determine the prevalence of past hepatitis A virus (HAV) infection among children and young people in New Zealand.
- To investigate demographic and geographic disparities in HAV infection rates within this population.
Main Methods:
- Assayed 2000 serum samples collected nationwide in 1978-79 for antibody to hepatitis A virus (anti-HAV).
- Analyzed sera from individuals aged 0-21 years across all New Zealand health districts.
- Calculated prevalence rates, age-standardized rates, and risk ratios stratified by sex, ethnicity, and geographic region.
Main Results:
- Overall prevalence of anti-HAV was 15.4% (307/2000).
- Prevalence increased with age through childhood and adolescence.
- Significantly higher age-standardized prevalence in Māori (39.5%) compared to Europeans (16.1%), with a risk ratio of 2.1.
- A marked north-south gradient observed: northern North Island children (19.8%) had a 3.8 times higher risk ratio than South Island children (5.2%).
- No significant sex differential in prevalence was found.
Conclusions:
- Hepatitis A infection demonstrated significant ethnic and geographic disparities in New Zealand youth during 1978-79.
- Māori children and those residing in the northern North Island exhibited substantially higher infection rates.
- These findings highlight the need for geographically and ethnically targeted public health interventions for hepatitis A.
Abstract:
Antibody to hepatitis A virus (anti HAV), a marker of past infection, was assayed in 2000 sera collected as part of a national survey in 1978-79. The sera were obtained from children and young people aged 0-21 years, resident in all health districts of New Zealand. Anti HAV was detected in 307 sera, giving an overall prevalence of 15.4%. Prevalence increased steadily throughout childhood but more slowly during adolescence. There was no sex differential, the age-standardised rate/100 being 15.5 (95% confidence interval 13.2, 17.8) for males and 16.6 (14.4, 18.9) for females. However, the age-standardised rate for Maoris was 39.5 (33.2, 45.8) compared to 16.1 (12.8, 19.4) for Europeans, giving a risk ratio of 2.1. In addition, a marked north-south gradient in prevalence was demonstrated: the rate for children in the northern half of the North Island, when standardised for age and ethnicity, was 19.8 (16.8, 22.7) compared to 5.2 (3.2, 7.1) for South Island children, giving a risk ratio of 3.8. The higher prevalence of hepatitis A infection in Maori and northern North Island children mirrors our previously reported findings regarding markers of hepatitis B infection in this serum collection.
Related Concept Videos
Poliomyelitis
Hepatitis
Toxoplasmosis
Amebiasis
Viral Hepatitis I: Introduction

