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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

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Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
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What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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Related Experiment Video

Updated: Feb 5, 2026

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
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Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

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Genome-Wide Expression Profiles for Ischemic Stroke: A Meta-Analysis.

Carlos E Moreno-Ramírez1, Eulogia Gutiérrez-Garzón1, George E Barreto2

  • 1Laboratory of Neuropsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|September 1, 2018
PubMed
Summary
This summary is machine-generated.

This meta-analysis identified 41 differentially expressed genes in ischemic stroke (IS) pathophysiology. Key findings highlight the inflammatory response and PAX2 transcription factor in IS development.

Keywords:
Ischemic strokebioinformaticscomputational biologygenome-wide expressionmeta-analysisneurogenetics

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Last Updated: Feb 5, 2026

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Ischemic stroke (IS) is a leading cause of mortality and disability worldwide.
  • Genome-wide expression studies (GWES) using microarrays have advanced understanding of IS molecular mechanisms.

Purpose of the Study:

  • To conduct a meta-analysis of available GWES for IS.
  • To identify enriched functional categories and convergence with other genomic datasets for IS.

Main Methods:

  • Meta-analysis of three primary GWES datasets for IS.
  • Bioinformatics and computational biology analyses were employed.
  • Random effects model used for identifying differentially expressed genes.

Main Results:

  • Identified 41 differentially expressed (DE) genes in IS: 13 downregulated and 28 upregulated.
  • Significant enrichment for the Gene Ontology Term "Inflammatory Response".
  • Enrichment found for binding sites of the PAX2 transcription factor.

Conclusions:

  • The identified DE genes provide a valuable resource for future IS genetic and molecular research.
  • Novel mechanisms in IS pathophysiology can be uncovered through further studies.
  • The role of inflammatory response in IS pathophysiology is reinforced.