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Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials

Jin-Dong Zhao1, Jing-Jing Jia1, Ping-Shuan Dong1

  • 1Department of Cardiology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.

BMJ Open
|September 1, 2018
PubMed

Insights

Vitamin D supplementation can help reduce ventricular remodelling in heart failure (HF) patients. This meta-analysis found vitamin D improved cardiac function by decreasing left ventricular end-diastolic dimension and increasing ejection fraction.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nutritional Science

Background:

  • Vitamin D deficiency is linked to heart failure (HF) development and progression.
  • The efficacy of vitamin D supplementation in improving ventricular remodelling in HF patients remains unclear.

Purpose of the Study:

  • To systematically evaluate the influence and safety of vitamin D supplementation on ventricular remodelling in HF patients.
  • To assess the impact of vitamin D on cardiac function parameters like LVEDD and LVEF.

Main Methods:

  • Meta-analysis of randomized controlled trials (RCTs).
  • Searched multiple databases (PubMed, EMBASE, CNKI, Cochrane, Web of Science) and grey literature.
  • Included 7 RCTs with 465 patients (235 vitamin D group, 230 control).

Main Results:

  • Vitamin D group showed a significant decrease in left ventricular end-diastolic dimension (LVEDD) (MD=-2.31 mm, p=0.01).
  • Vitamin D group demonstrated a significant increase in left ventricular ejection fraction (LVEF) (MD=4.18%, p=0.03).
  • High-dose vitamin D (>4000 IU/day) and supplementation in patients with reduced ejection fraction showed greater benefits.

Conclusions:

  • Vitamin D supplementation effectively inhibits ventricular remodelling in HF patients.
  • Vitamin D improves cardiac function in heart failure patients.
  • The findings support vitamin D as a potential therapeutic agent for managing HF.
Abstract

Keywords:
cardiac functionheart failuremeta-analysisventricular remodelingvitamin D

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