Related Experiment Video
Updated: Feb 5, 2026

Multifocal Electroretinograms
Published on: December 4, 2011
[Pattern electroretinogram and macular perfusion in glaucoma]
N I Kurysheva1, E V Maslova1, A V Trubilina1
1Consultative-diagnostic Department of Ophthalmology Center of the Federal Medical and Biological Agency, Burnasyan Federal Medical Biophysical Center of FMBA, Department of Ophthalmology at Institute of Advanced Training of FMBA, 15 Gamalei St., Moscow, Russian Federation, 123098.
Purpose:
To study microcirculatory and functional changes in macula in patients with Primary Open-Angle Glaucoma (POAG).
Material And Methods:
The study included 95 POAG patients and 42 healthy control subjects. Whole en face image vessel density (wiVDRetina) was measured both in fovea and in parafovea using OCT-angiography (OCT-A) by means of SD-OCT AngioVue on Avanti RtVue xR (Optovue Inc., U.S.A.). Macular thickness and parameters of macular ganglion cell complex (GCC) were measured on the same day. Blood flow in the retrobulbar vessels was evaluated by means of Color Doppler Imaging (CDI). Pattern electroretinogram (PERG) was also taken from the study eyes. Correlations between PERG, SD-OCT GCC, macular thickness, and the parameters of OCT-A and CDI were studied.
Results:
The amplitude of t-PERG P50 decreased from 6.1±1.3 µV in normal eyes to 2.8±1.6 µV (p<0.0001) in early glaucoma and to 2.3±1.5 µV (p=0.93) in advanced stages. Relative vessel density of the capillary bed decreased from 51.3±3.0% in normal eyes to 45.9±5.0% (p<0.001) and to 41.8±5.0% (p=0.023) in early and advanced glaucoma respectively. The parameters of OCT-A and CDI correlated with morphological and functional parameters in normal and early glaucomatous eyes.
Conclusion:
The study revealed reduction of macular microcirculation and decrease of PERG in early glaucoma. Correlations between the circulatory parameters and functional changes were found in early stages of the disease.
Related Concept Videos
Glaucoma: Overview
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Fixed Action Patterns
Patterns of Fever
Assessment of Diffusion and Perfusion
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...

