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Updated: Feb 5, 2026
Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery
Published on: August 16, 2019
Effect of elective percutaneous coronary intervention of left anterior descending coronary artery on regional
Gehan Magdy1, Mohammed Sadaka1, Tarek Elzawawy1
1Department of Cardiology, Alexandria University, Egypt.
Insights
Tissue Doppler imaging effectively assesses left ventricular systolic function after percutaneous coronary intervention (PCI) in stable coronary artery disease patients. Strain and strain rate imaging show significant improvement three months post-PCI.
Area of Science:
- Cardiology
- Medical Imaging
- Echocardiography
Background:
- Stable coronary artery disease (CAD) patients often have undiagnosed regional myocardial dysfunction.
- Percutaneous coronary intervention (PCI) is a common revascularization procedure.
Purpose of the Study:
- To evaluate left ventricular (LV) systolic function improvement after elective PCI of the left anterior descending artery (LAD).
- To assess regional myocardial function using strain and strain rate imaging techniques.
Main Methods:
- 30 stable CAD patients undergoing elective LAD PCI were studied.
- Tissue Doppler imaging (TDI) assessed LV function pre-PCI, immediately post-PCI, and 3 months post-PCI.
- Peak systolic longitudinal strain (PSLS) and peak systolic strain rate (PSSR) were measured in LAD segments.
Main Results:
- Patients had lower PSLS and PSSR in ischemic segments compared to controls.
- PSLS and PSSR significantly increased 3 months post-PCI, not immediately.
- PSLS cutoff of -13.69% detected regional ischemia with 93.3% sensitivity and 80% specificity.
Conclusions:
- TDI-derived strain and strain rate detect myocardial dysfunction in preserved LV function.
- These techniques assess regional function improvement post-PCI in stable CAD.
Background:
Percutaneous coronary intervention (PCI) is a commonly used procedure for revascularization, however the impairment of regional myocardial function in patients with stable coronary artery disease (CAD) has not been well characterized, our study aimed to assess the improvement of left ventricular (LV) systolic function after elective PCI of the left anterior descending artery (LAD) using strain and strain rate imaging techniques.
Materials And Methods:
The study included 30 patients (aged 56.8 ± 6.6 years, 66.7% males) presented with stable CAD on optimal medical therapy, and recommended for elective PCI to LAD, all patients included in the study had a normal LV wall motions, and normal LV systolic function. Tissue Doppler imaging (TDI) was done before PCI, immediately, and three months post PCI. The peak systolic longitudinal strain (PSLS), and peak systolic strain rate (PSSR) were measured and averaged for the 6 LAD segments (the basal, mid, and apical segments of the anterior wall, the basal, mid anteroseptal, and the apicoseptal segments), 15 healthy control subjects were included as a control group.
Results:
The average PSLS and PSSR of the ischemic segments were significantly lower in patients compared to control in the ischemic segments, and significantly increased 3 months post PCI but not immediately post PCI. Using the ROC curve a cutoff value of -13.69% for PSLS can detect regional ischemia with a sensitivity 93.3% and a specificity of 80%.
Conclusions:
TDI derived strain and strain rate can detect resting regional myocardial dysfunction in presence of preserved LV systolic function, and can assess the improvement of regional myocardial function after successful elective PCI in patients with stable CAD.
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