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Inflammation and atrial fibrillation: A comprehensive review
Panagiotis Korantzopoulos1, Konstantinos P Letsas2, Gary Tse3,4
1First Department of Cardiology Medical School University of Ioannina Ioannina Greece.
Journal of Arrhythmia
|September 1, 2018
Summary
Inflammation plays a key role in atrial remodeling, a process underlying atrial fibrillation (AF). While inflammatory markers predict AF, anti-inflammatory treatments show variable results, posing challenges for future strategies.
Area of Science:
- Cardiology
- Immunology
- Pathophysiology
Background:
- Atrial fibrillation (AF) involves atrial remodeling, characterized by electrophysiological and structural changes.
- Inflammation is increasingly recognized as a critical factor in the pathophysiology of atrial remodeling and AF.
- Various underlying conditions contribute to the complex interplay between inflammation and atrial remodeling.
Purpose of the Study:
- To review the current understanding of inflammation's role in atrial remodeling and AF.
- To examine the predictive value of inflammatory markers in AF.
- To critically discuss existing and future anti-inflammatory strategies for AF.
Main Methods:
- Review of experimental and clinical data on inflammation in AF.
- Analysis of the association between inflammatory markers and AF development, recurrence, and complications.
- Evaluation of anti-inflammatory agents tested in AF.
Main Results:
- Inflammatory markers are linked to AF development, perpetuation, burden, and thromboembolic risk.
- The mechanistic links between atrial remodeling and inflammation are complex and multifactorial.
- Anti-inflammatory interventions have yielded variable results, indicating challenges in therapeutic development.
Conclusions:
- Inflammation is a significant contributor to atrial remodeling and AF.
- Inflammatory markers serve as important predictors of AF.
- Developing effective anti-inflammatory strategies for AF requires further research and consideration of pleiotropic agents.
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