Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nonlinear Pharmacokinetics: Causes of Nonlinearity01:22

Nonlinear Pharmacokinetics: Causes of Nonlinearity

737
Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens.
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...
737
Application of Nonlinear Inequalities01:29

Application of Nonlinear Inequalities

255
A nonlinear inequality describes a comparison involving an expression that curves or behaves more complexly than a straight line. These inequalities often appear in forms that include squares, products, or variables in the denominator.To solve such an inequality, one starts by rewriting it so that zero appears on one side. For example, the inequality:  can be factored as: This form makes it easier to identify the values that cause the expression to equal zero. In this case, the...
255
Introduction to Nonlinear Inequalities01:25

Introduction to Nonlinear Inequalities

229
Linear and nonlinear inequalities are fundamental for analyzing variable relationships and identifying ranges satisfying specific conditions. A linear inequality involves variables raised only to the first power, resulting in a straight-line graph. This line partitions the coordinate plane into two distinct regions: one that satisfies the inequality and one that does not. Each region represents a set of solutions where the linear relationship holds true under the specified constraint.Nonlinear...
229
Nonlinear Pharmacokinetics: Overview01:19

Nonlinear Pharmacokinetics: Overview

1.1K
Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...
1.1K
Nonlinear Pharmacokinetics: Role of Transporters01:27

Nonlinear Pharmacokinetics: Role of Transporters

295
A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
Polymorphisms occurring in drug transporters can alter...
295
Nonlinear Pharmacokinetics: Michaelis-Menten Equation01:18

Nonlinear Pharmacokinetics: Michaelis-Menten Equation

1.1K
The Michaelis–Menten equation is a fundamental model for describing capacity-limited kinetics in drug metabolism. It offers insights into the rate of decline of plasma drug concentration Cp over time, with Vmax and KM as pivotal parameters.
Vmax represents the maximum achievable process rate, while KM, known as the Michaelis constant, signifies the drug concentration at which the process rate reaches half its maximum. This relationship between Vmax, KM, and Cp gives rise to three distinct...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Application of Wharton's Jelly Derived from Human Umbilical Cord in Tissue Engineering.

Current stem cell research & therapy·2026
Same author

Discovery and Optimization of Novel Carbazole-Based Ferroptosis Inhibitors.

Chemistry & biodiversity·2026
Same author

Time in target systolic blood pressure range and cardiometabolic disease-free life expectancy in hypertensive elderly.

American journal of preventive cardiology·2026
Same author

Nonvolatile phase-programmable spintronic terahertz emitter via laser-induced spin polarization switching.

National science review·2026
Same author

Synthesis and Preliminary Evaluation of the <sup>211</sup>At-Labeled PARP Inhibitor [<sup>211</sup>At]Talazoparib as a Targeted Alpha-Particle Emitting Therapeutic.

Molecular pharmaceutics·2026
Same author

The proportion of moderate-to-vigorous-intensity physical activity to total volume of physical activity is associated with cognitive and mental health in middle-aged and older adults.

BMC psychology·2026

Related Experiment Video

Updated: Feb 5, 2026

Design, Fabrication, and Experimental Characterization of Plasmonic Photoconductive Terahertz Emitters
10:54

Design, Fabrication, and Experimental Characterization of Plasmonic Photoconductive Terahertz Emitters

Published on: July 8, 2013

15.3K

Nonlinear terahertz devices utilizing semiconducting plasmonic metamaterials.

Huseyin R Seren1, Jingdi Zhang2,3, George R Keiser2,4

  • 1Laboratory for Microsystems Technology, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA.

Light, Science & Applications
|September 1, 2018
PubMed
Summary

We developed metal-free terahertz metamaterials using indium arsenide (InAs) plasmonic disks. These nonlinear metamaterials function as optical limiters and saturable absorbers, showing potential for ultrafast optics.

Keywords:
nonlinear absorbersnonlinear metamaterialsplasmonic semiconductor metamaterialsterahertz metamaterialstransfer printing

More Related Videos

Fabricating Metamaterials Using the Fiber Drawing Method
11:57

Fabricating Metamaterials Using the Fiber Drawing Method

Published on: October 18, 2012

14.3K
Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle
15:06

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Published on: January 3, 2016

13.4K

Related Experiment Videos

Last Updated: Feb 5, 2026

Design, Fabrication, and Experimental Characterization of Plasmonic Photoconductive Terahertz Emitters
10:54

Design, Fabrication, and Experimental Characterization of Plasmonic Photoconductive Terahertz Emitters

Published on: July 8, 2013

15.3K
Fabricating Metamaterials Using the Fiber Drawing Method
11:57

Fabricating Metamaterials Using the Fiber Drawing Method

Published on: October 18, 2012

14.3K
Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle
15:06

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Published on: January 3, 2016

13.4K

Area of Science:

  • Photonics
  • Materials Science
  • Optics

Background:

  • Responsive metamaterials enable tunable photonic devices.
  • Semiconductor-integrated metallic resonators create nonlinear metamaterials.
  • Metal-free resonant semiconductor structures offer an alternative for dynamic metamaterials.

Purpose of the Study:

  • To present indium arsenide (InAs) plasmonic disk arrays as a viable resonant metamaterial for terahertz frequencies.
  • To demonstrate the nonlinear optical properties of InAs plasmonic disks.
  • To explore applications in nonlinear perfect absorbers.

Main Methods:

  • Fabrication of InAs plasmonic disk arrays.
  • Characterization of terahertz (THz) resonant properties.
  • Investigation of nonlinear optical response mechanisms, including electric field-induced intervalley scattering.

Main Results:

  • InAs plasmonic disks exhibit strong terahertz resonance.
  • A significant nonlinear response was observed due to electric field-induced intervalley scattering, reducing carrier mobility and damping the plasmonic response.
  • Nonlinear perfect absorbers were demonstrated as optical limiters and saturable absorbers, including flexible versions on polyimide films.

Conclusions:

  • InAs plasmonic disk arrays are effective metal-free terahertz metamaterials.
  • The observed nonlinear response enables applications in optical limiting and saturation.
  • These nonlinear plasmonic metamaterials hold promise for ultrafast THz optics and electromagnetic device protection.