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Ticagrelor Removal From Human Blood
George O Angheloiu1,2,3, Gabriel B Gugiu4, Cristian Ruse5
1Massachusetts Institute of Technology, Cambridge, Massachusetts.
JACC. Basic to Translational Science
|September 1, 2018
Summary
Sorbent hemadsorption efficiently removes ticagrelor from blood. This method achieved over 99% ticagrelor removal in vitro, demonstrating its effectiveness for potential therapeutic applications.
Area of Science:
- Pharmacology
- Biomedical Engineering
- Toxicology
Background:
- Ticagrelor is an antiplatelet medication.
- Efficient methods for drug removal from blood are crucial for managing overdoses or toxicity.
- Hemadsorption is a potential extracorporeal technique for substance removal.
Purpose of the Study:
- To develop and evaluate an efficient sorbent hemadsorption method for ticagrelor removal from blood.
- To quantify the efficacy of hemadsorption in removing ticagrelor from both artificial solutions and human blood samples.
Main Methods:
- In vitro experiments were conducted using bovine serum albumin (BSA) solution and human blood.
- Two experimental setups were used: a first-pass experiment and a recirculating system.
- Ticagrelor removal was measured using the sorbent hemadsorption technique.
Main Results:
- Hemadsorption achieved >99% ticagrelor removal from BSA solution.
- In recirculating experiments, peak ticagrelor removal from whole blood was 99% and 94% over 10 hours.
- Peak removal from plasma was 99.99% and 90% over 3-4 hours.
Conclusions:
- Sorbent hemadsorption is a robust and effective method for removing ticagrelor.
- The technique demonstrates high efficiency in both artificial solutions and human blood matrices.
- Hemadsorption shows promise as a therapeutic strategy for ticagrelor removal.
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