Foot shock induces time and region specific adrenergic receptor changes in rat brain

Rats were subjected to 1 hr or 2 hr of electric foot shock for 1 day or 7 days and adrenergic receptor binding was evaluated in the hypothalamus, brainstem and cortex. beta-Adrenergic receptor density in the hypothalamus was dramatically reduced following 1 hr of shock. Following repeated shock, alpha 2-adrenergic receptors in the cortex and brainstem were observed to increase. Cortical alpha 2-adrenergic receptors were more sensitive to stress than the alpha 2-adrenergic receptors of the brainstem, alterations in the latter only reaching statistical significance following 7 days of shock and 24 hr of recovery. alpha 1- and beta-adrenergic receptors in the brainstem and cortex were relatively resistant to stress induced changes. The significance of type of stress, duration of stress, and strain of rat for understanding the current data are discussed in the context of prior reports of stress induced receptor changes.