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The neuromuscular blocking activity of spectinomycin on the rat sciatic nerve-gastrocnemius muscle preparation
Pharmacological Research Communications
|May 1, 1986
Abstract:
Spectinomycin displays a dose-dependent neuromuscular blocking activity in vivo. The neuromuscular blockade elicited by spectinomycin is potentiated by d-tubocurarine. Neostigmine methylsulfate is unable to reverse the neuromuscular blocking activity of spectinomycin, whereas calcium chloride counteracts the neuromuscular blockade induced by this antibiotic.