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Aspergillus terreus Causing Probable Invasive Aspergillosis in a Patient with Cystic Fibrosis
Shreya Singh1, Harsimran Kaur2, Meenu Singh3
1Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Abstract:
Aspergillus terreus may colonize the airways of patients with cystic fibrosis (CF). Whether this merits antifungal treatment is still unclear due to heterogeneous reports regarding its pathogenic potential. Although allergic manifestations are documented, invasive aspergillosis (IA) caused by A. terreus has not been described. We present here one case of probable IA caused by A. terreus, highlighting its role as an emerging agent of IA in CF patients. Voriconazole was effective, and the patient was healthy after 12 weeks of treatment. Serial determination of serum galactomannan level and periodic cultures from respiratory specimens may help in monitoring CF patients by identifying such pathogens. Further studies on the fungal species colonizing the CF airways are warranted, especially in India. This case report suggests A. terreus as a potential agent of IA which should not be ignored, particularly in this patient group.
Insights
Aspergillus terreus can colonize cystic fibrosis (CF) airways. This case highlights A. terreus as an emerging cause of invasive aspergillosis (IA) in CF patients, effectively treated with voriconazole.
Area of Science:
- Mycology
- Infectious Diseases
- Pulmonology
Background:
- Aspergillus terreus commonly colonizes the airways of cystic fibrosis (CF) patients.
- The pathogenic potential of A. terreus in CF is not well-defined, with varied reports on its clinical significance.
- Invasive aspergillosis (IA) caused by A. terreus has not been previously described in CF patients.
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