Vancomycin-induced red man syndrome presentation in a preterm infant
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Updated: Feb 5, 2026

Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants
Published on: January 26, 2019
Silvia Martini1, Rosina Alessandroni1, Santo Arcuri1
1Neonatology and Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences (DIMEC), St. Orsola-Malpighi Hospital-University of Bologna, Bologna, Italy.
Abstract:
A male infant born at 32 weeks' gestation with a birthweight of 1030 g was started on intravenous vancomycin for a femoral osteomyelitis. On day 7 of treatment, he developed an erythematous flushed rash, rapidly spreading from the head to trunk and extremities, and became markedly irritable; vancomycin infusion was promptly stopped, with subsequent skin clearance. Given the wide use of vancomycin for the treatment of neonatal infections, a good awareness of red man syndrome signs and symptoms in the neonatal population is fundamental to recognize this adverse drug reaction and manage its rare but possible life-threatening complications.
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