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The ITS2 Database
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Basic characteristics and representativeness of the German Disease Analyzer database
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Wolfgang Rathmann, Brenda Bongaerts, Hans-Joachim Carius

    International Journal of Clinical Pharmacology and Therapeutics
    |September 1, 2018
    PubMed
    Summary

    The Disease Analyzer (DA) database accurately represents major chronic diseases like cancer and dementia in Germany. Diabetes prevalence is higher in DA due to more frequent patient visits.

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    Area of Science:

    • Epidemiology
    • Health Informatics
    • Public Health

    Background:

    • The Disease Analyzer (DA) database collects anonymized longitudinal data from German primary care practices.
    • It includes drug prescriptions, diagnoses, and demographic information for millions of patients.
    • Assessing the representativeness of this database for chronic diseases is crucial for epidemiological research.

    Purpose of the Study:

    • To evaluate the accuracy of diagnoses for major chronic diseases (cancer, dementia, diabetes) within the Disease Analyzer database.
    • To compare DA data with national reference data for these conditions.

    Main Methods:

    • Analyzed cancer incidence by subsite, dementia prevalence by age and sex, and diabetes prevalence using DA data.
    • Compared DA findings with official national reference data for Germany.
    • Utilized longitudinal data from 2,498 practices representing 7.8 million patients in 2017.

    Main Results:

    • DA patient demographics (age, sex) closely mirrored the general German population.
    • Cancer subsite distribution in DA showed good agreement with national data (e.g., breast cancer).
    • Dementia prevalence by age and sex in DA aligned well with national reference data.
    • Diabetes prevalence in DA (10.7%) was higher than in other German health data sources.

    Conclusions:

    • The Disease Analyzer database demonstrates good agreement with German reference data for the incidence and prevalence of major chronic diseases.
    • The observed higher diabetes prevalence in DA is attributed to increased outpatient visits by diabetes patients.
    • DA is a valuable resource for epidemiological studies on chronic diseases in Germany.