Related Experiment Video

Updated: Feb 5, 2026

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K

Hepatitis B & C virus infection in HIV seropositive individuals & their association with risk factors: A

Vineeta Sharma1, V G Ramachandran2, Narendra Singh Mogha2

  • 1Division of Molecular Genetics & Biochemistry, ICMR-National Institute of Cancer Prevention & Research, Noida, India.

The Indian Journal of Medical Research
|September 1, 2018
PubMed

Insights

Hepatitis B and C virus co-infection is significantly higher in HIV-positive individuals. Routine hepatitis virus screening for HIV patients is recommended to monitor liver health and prevent cirrhosis.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause liver inflammation.
  • HBV and HCV infections are prevalent in individuals with human immunodeficiency virus (HIV).
  • Co-infection with HBV and HCV can exacerbate liver disease progression in HIV patients.

Purpose of the Study:

  • To determine the prevalence of HBV and HCV co-infection in HIV-positive and HIV-negative individuals.
  • To investigate the association of hepatitis virus co-infection with risk factors in north India.
  • To assess the clinical implications of hepatitis virus co-infection in HIV-infected patients.

Main Methods:

  • Analysis of 840 serum samples (440 HIV-positive, 400 HIV-negative controls).
  • Detection of HBV and HCV infections using serological assays.
  • Statistical analysis to identify associations with age and transmission routes.

Main Results:

  • HCV prevalence was 13% and HBV was 11% among HIV-positive individuals.
  • Prevalence of HBV and HCV in controls was 2% and 3%, respectively.
  • Age group 21-40 and heterosexual contact were significantly associated with HBV and HCV infection.

Conclusions:

  • HBV and HCV co-infection rates are significantly higher in HIV-positive individuals compared to the general population.
  • Hepatitis virus infections accelerate liver cirrhosis in HIV-infected patients.
  • Regular hepatitis virus screening is crucial for monitoring HIV-positive patients and managing clinical outcomes.
Abstract

Keywords:
Co-infection - hepatitis B - hepatitis C - HIV

More Related Videos

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals09:27

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Published on: May 30, 2013

11.7K
Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays13:58

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

Published on: September 26, 2011

32.2K

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.6K
Hospitals-II00:59

Hospitals-II

Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in...
1.2K
Hospitals-I01:28

Hospitals-I

Hospitals offer medical and surgical care to the sick and injured, along with accommodation while they recover. At the same time, they also provide outpatient, emergency, psychiatric, and rehabilitation services to meet various community needs. In addition to providing medical care, hospitals also act as hubs for medical research and training. Hospitals use clinical procedures and evidence-based practice standards to deliver patient care. To deliver safe and efficient care, a nurse must stay up...
1.7K
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
590
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.7K
What are Viruses?00:50

What are Viruses?

Overview
128.3K