Related Experiment Video

Updated: Feb 5, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

1.6K

Chronic dialysis in children and adolescents: challenges and outcomes

Lesley Rees1, Franz Schaefer2, Claus Peter Schmitt2

  • 1Renal Office, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

The Lancet. Child & Adolescent Health
|September 1, 2018
PubMed

Insights

Chronic dialysis for children is uncommon but associated with higher risks than transplantation. Limited resources worldwide hinder access to this life-sustaining treatment for pediatric end-stage kidney disease.

Area of Science:

  • Pediatric Nephrology
  • Renal Replacement Therapy

Background:

  • Chronic dialysis is infrequently needed in childhood.
  • Despite advancements, pediatric dialysis carries higher morbidity and mortality than renal transplantation.
  • Global financial constraints limit access to pediatric dialysis services.

Purpose of the Study:

  • To review the incidence and causes of end-stage kidney disease in children requiring long-term dialysis.
  • To highlight key management issues in pediatric chronic dialysis.
  • To present patient outcome data for pediatric dialysis.

Main Methods:

  • Literature review of pediatric end-stage kidney disease.
  • Analysis of dialysis modality selection and complications.
  • Review of patient outcome data.

Main Results:

  • Pediatric end-stage kidney disease requiring chronic dialysis is rare.
  • Higher morbidity and mortality observed in children on dialysis compared to transplant recipients.
  • Significant global disparities in dialysis availability due to cost and personnel.

Conclusions:

  • Renal transplantation is generally preferred over chronic dialysis for children.
  • Management of pediatric dialysis requires careful consideration of modality, complications, and outcomes.
  • Improving access to pediatric dialysis in resource-limited settings is a global challenge.

More Related Videos

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

2.7K
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.9K

Related Concept Videos

Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
1.5K
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
1.8K
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
808
Cognitive Development During Adolescence01:18

Cognitive Development During Adolescence

During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
621
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.9K
Peritoneal Dialysis I: Introduction and Procedure01:30

Peritoneal Dialysis I: Introduction and Procedure

Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
3.2K