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Information transmission in HPC-PFC network for spatial working memory in rat.
Mi Xia1, Tiaotiao Liu1, Wenwen Bai1
1School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, 300070, China.
Behavioural Brain Research
|September 1, 2018
Summary
Information flow between the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) increases during spatial working memory tasks. This enhanced vHPC to mPFC communication predicts accurate memory recall in rats.
Area of Science:
- Neuroscience
- Cognitive Science
- Systems Neuroscience
Background:
- Spatial working memory relies on the hippocampus (HPC) and prefrontal cortex (PFC).
- The precise directional communication within the HPC-PFC network for spatial memory is not fully understood.
Purpose of the Study:
- To investigate the directional information flow between the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) during a spatial working memory task.
- To determine the role of vHPC-mPFC information transmission in memory accuracy.
Main Methods:
- Neuronal activity was recorded from rat vHPC and mPFC during a Y-maze spatial working memory task.
- Causal connectivity and information flow were calculated using maximum likelihood estimation.
Main Results:
- Bidirectional information flow between vHPC and mPFC increased during the task.
- Increased information flow in both directions correlated with correct memory responses.
- Information flow from vHPC to mPFC was significantly higher and preceded the flow from mPFC to vHPC.
Conclusions:
- Direct information transmission from vHPC to mPFC appears predominant for spatial working memory in rats.
- The directionality and accuracy of information flow are critical for successful spatial memory encoding and retrieval.
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