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Published on: January 21, 2020
One-year clinical outcomes of different coronary drug eluting stents-Data from a prospective registry
B K S Sastry1, Krishna Reddy Nallamalla2, Nirmal Kumar1
1CARE Hospital, Jawaharlal Nehru Road, Nampally, Hyderabad, Telangana, 500001, India.
Insights
This study found no significant difference in one-year clinical outcomes between imported and Indian drug-eluting stents (DES). Both stent types demonstrated comparable safety and efficacy in preventing mortality, stent thrombosis, and revascularization.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Biomaterials Science
Background:
- Drug-eluting stents (DES) are crucial in percutaneous coronary interventions.
- A prospective registry compared outcomes of imported versus indigenous DES.
- Focus on cost-effective Indian DES lacking extensive clinical trials.
Discussion:
- Propensity score matching ensured comparable patient groups.
- One-year follow-up data analyzed for primary composite endpoint (mortality, stent thrombosis, revascularization).
- No significant differences observed between imported and indigenous DES groups.
Key Insights:
- Indigenous drug-eluting stents (DES) show comparable one-year clinical outcomes to imported DES.
- Cost-effective Indian DES provide a viable alternative without compromising patient safety or efficacy.
- Study addresses the clinical performance of economical DES in a real-world setting.
Outlook:
- Further long-term studies can validate these findings.
- Potential for wider adoption of cost-effective indigenous DES.
- Implications for healthcare policy and patient access to cardiovascular treatments.
Abstract:
We compared one-year clinical outcomes of different drug eluting stents (DES) used in a prospective observation registry maintained in two hospitals over three years. The primary endpoint was combination of all-cause mortality, stent thrombosis and revascularization. There was no significant difference among different DES. We grouped DES into well-evaluated Imported DES (Imported group), which used to be expensive prior to price control and economical Indian DES (Indigenous group) that lack supportive clinical trials. One-year follow-up data was available in 99% of Indigenous group (n=1856) and 98.5% of Imported group (n=1539). After propensity score matching, there were 1310 matched pairs. There was no significant difference between two groups in the primary end-point or each of the components.
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