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Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis
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Systemic inflammatory markers in relation to lung function in NHANES. 2007-2010.

Elisabet Nerpin1, Tiago Jacinto2, João A Fonseca3

  • 1Dept. of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden; Dept. of Medicine, Health and Social Studies, Dalarna University, Falun, Sweden; Dept. of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.

Respiratory Medicine
|September 2, 2018
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Summary

Inflammatory markers like C-reactive protein (CRP), blood eosinophils, and neutrophils are linked to reduced lung function. Combining these markers provides additive information for assessing lung health in the general population.

Keywords:
Blood eosinophilsBlood neutrophilsCRPInflammation

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Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Public Health

Background:

  • Low-grade systemic inflammation, often measured by C-reactive protein (CRP), is associated with diminished lung function.
  • Limited research has explored whether CRP, blood eosinophils, and blood neutrophils offer complementary insights into lung function.
  • Understanding the interplay of these inflammatory markers is crucial for assessing respiratory health.

Purpose of the Study:

  • To investigate the associations between lung function parameters and inflammatory markers: CRP, blood eosinophils, and blood neutrophils.
  • To determine if combining these inflammatory markers provides additive information beyond individual assessments.
  • To analyze gender-based differences in these associations.

Main Methods:

  • A cross-sectional study involving 7753 adults aged 20-80 years from the National Health and Nutrition Examination Survey.
  • Analysis of gender-based tertiles for CRP, blood eosinophils, and blood neutrophils.
  • Lung function was assessed using forced expiratory volume in 1 second (FEV1 % predicted), forced vital capacity (FVC % predicted), and the FEV1/FVC ratio.

Main Results:

  • Elevated levels of CRP, blood eosinophils, and blood neutrophils were inversely associated with FEV1 and FVC.
  • Blood eosinophils and blood neutrophils showed an inverse relationship with the FEV1/FVC ratio.
  • A dose-response relationship was observed, with increasing numbers of elevated inflammatory markers correlating with significantly lower FEV1 and FVC.

Conclusions:

  • CRP, blood eosinophils, and blood neutrophils provide independent and additive information regarding reduced FEV1 and FVC in the general population.
  • The combined assessment of these biomarkers offers greater insight into lung function compared to individual marker evaluation.
  • These findings highlight the clinical relevance of utilizing a multi-biomarker approach for a comprehensive understanding of lung health.