Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MAPK Signaling Cascades01:07

MAPK Signaling Cascades

8.4K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
8.4K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

10.1K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.1K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

8.5K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.5K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

10.6K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Portable electronic devices for mechanotherapy and operative treatment of osteoarthritis.

Mechanobiology in medicine·2026
Same author

Ultrasound-Treated <i>Dendrobium officinale</i> Polysaccharides as Functional Ingredients for Plant-Based Yogurt: Enhancing Gel Properties of Soy Protein Isolate.

Gels (Basel, Switzerland)·2026
Same author

Effect of Substrate Bias on the Microstructure and Properties of CrAlSiN Composite Coatings.

Nanomaterials (Basel, Switzerland)·2026
Same author

Cost-effective ecological monitoring in shallow waters using amphibious unmanned aerial vehicles (AUAV) and deep learning-based computer vision.

Marine environmental research·2026
Same author

Schiff base-reduced chitosan aerogels with enhanced iodine capture: 3D nano-porous networks for efficient iodine-contaminated water remediation.

International journal of biological macromolecules·2026
Same author

Organ toxicity of Paris polyphylla in mice and the underlying hepatotoxic mechanism uncovered by an integrated network toxicology and transcriptomics.

Journal of ethnopharmacology·2026
Same journal

[Research progress on multimodal precision nursing interventions in urinary incontinence rehabilitation management after radical prostatectomy].

Zhonghua nan ke xue = National journal of andrology·2025
Same journal

[Dietary intervention to improve erectile dysfunction: Progress in research].

Zhonghua nan ke xue = National journal of andrology·2025
Same journal

[Tonifying kidney and activating blood therapy for the treatment of diabetic erectile dysfunction: A systematic review and meta-analysis].

Zhonghua nan ke xue = National journal of andrology·2025
Same journal

[Clinical effect of Huotujiji prescription on patients with asthenospermia of spleen-kidney yang-deficiency type].

Zhonghua nan ke xue = National journal of andrology·2025
Same journal

[Application of predictive nursing to the rehabilitation of patients after endoscopic surgery for prostate under the concept of enhanced recovery after surgery].

Zhonghua nan ke xue = National journal of andrology·2025
Same journal

[Influencing factors of lower urinary tract symptoms in patients after radical prostatectomy and nursing strategy].

Zhonghua nan ke xue = National journal of andrology·2025
See all related articles

Related Experiment Video

Updated: Feb 5, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.0K

[MAPK signaling pathway and erectile dysfunction].

Si-Xiang Chen1, Fan Zhao1, Xiao-Jun Huang2

  • 1The Second School of Clinical Medicine, Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang 310053, China.

Zhonghua Nan Ke Xue = National Journal of Andrology
|September 2, 2018
PubMed
Summary
This summary is machine-generated.

The MAPK signaling pathway, including ERK, JNK, and p38MAPK, is crucial for cell functions. This review explores its significant link to the development and progression of erectile dysfunction (ED).

Keywords:
c-Jun N-terminal kinaseextracellular signal-regulated kinasemitogen-activated protein kinasep38 mitogen-activated protein kinaseerectile dysfunction

More Related Videos

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

3.9K
Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System
08:54

Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System

Published on: March 20, 2016

10.3K

Related Experiment Videos

Last Updated: Feb 5, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.0K
Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

3.9K
Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System
08:54

Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System

Published on: March 20, 2016

10.3K

Area of Science:

  • Cellular signaling pathways
  • Molecular biology
  • Urology

Background:

  • The Mitogen-Activated Protein Kinase (MAPK) signaling pathway regulates critical cellular processes like differentiation, proliferation, and apoptosis.
  • Key MAPK family members include extracellular signal-regulated kinase (ERK), stress-activated protein kinase (JNK), and p38 mitogen-activated protein kinase (p38MAPK).

Purpose of the Study:

  • To review and elucidate the intricate correlation between the MAPK signaling pathway and the pathogenesis of erectile dysfunction (ED).
  • To consolidate current research on the roles of ERK, JNK, and p38MAPK in ED development and progression.

Main Methods:

  • Literature review of recent scientific studies.
  • Analysis of research focusing on MAPK signaling in cellular function and disease models of ED.

Main Results:

  • Emerging evidence indicates a strong association between dysregulation of ERK, JNK, and p38MAPK pathways and the onset and advancement of ED.
  • These pathways are implicated in the cellular mechanisms underlying erectile dysfunction.

Conclusions:

  • The MAPK signaling pathway represents a significant molecular mechanism implicated in erectile dysfunction.
  • Further investigation into MAPK signaling could reveal novel therapeutic targets for ED treatment.