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When orexins meet cannabinoids: Bidirectional functional interactions.

Fernando Berrendero1, África Flores2, Patricia Robledo3

  • 1Faculty of Experimental Sciences, Universidad Francisco de Vitoria, UFV, 28223 Pozuelo de Alarcón, Madrid, Spain; Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, 08003 Barcelona, Spain.

Biochemical Pharmacology
|September 2, 2018
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Summary
This summary is machine-generated.

Interactions between the endocannabinoid and orexin systems are increasingly evident. This review explores their cross-modulation in functions like pain, reward, and eating.

Keywords:
CannabinoidFeedingHeterodimersNociceptionOrexinReward

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Pharmacology

Background:

  • Evidence suggests biochemical and functional interactions between the endocannabinoid and orexin systems.
  • Cannabinoid and orexin receptors form heterodimers, with overlapping distributions in key brain areas.
  • Both systems converge on common intracellular signaling pathways, like the MAP kinase cascade.

Purpose of the Study:

  • To review the latest developments in cannabinoid-orexin cross-modulation.
  • To explore the implications of these interactions in physiological functions and behavior.

Main Methods:

  • Review of existing scientific literature on cannabinoid-orexin interactions.
  • Analysis of studies investigating receptor heterodimerization and signaling pathways.
  • Examination of behavioral studies demonstrating functional cross-talk.

Main Results:

  • Orexin receptor activation stimulates the synthesis of 2-arachidonoyl glycerol, an endocannabinoid.
  • Functional interactions are evident in behavioral responses, including nociception, reward, and food intake.
  • Cannabinoid-orexin cross-modulation influences several physiological processes.

Conclusions:

  • The endocannabinoid and orexin systems are intricately linked through biochemical and functional interactions.
  • Understanding this cross-modulation is crucial for comprehending physiological functions and potential therapeutic targets.
  • Further research into cannabinoid-orexin interactions may yield insights into treating conditions related to pain, reward, and appetite.