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Updated: Feb 5, 2026

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Mn2+ doped ZnS QDs modified fluorescence sensor based on molecularly imprinted polymer/sol-gel chemistry for
Zhihua Wang1, Yafang Zhang1, Bing Zhang1
1Key Laboratory of Bioelectrochemistry & Environmental Analysis of Gansu Province, College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China.
Abstract:
A newly fluorescence probe for detection of Serotonin based on a Mn-doped ZnS quantum dots@silica nanoparticle@molecularly imprinted polymers (QDs@SiO2@MIPs) was successfully created. QDs@SiO2@MIPs were characterized by scanning electron microscope, transmission electron microscope, Fourier transform infrared spectroscopy, UV spectroscopy, X-ray powder diffraction, and fluorescence spectroscopy. A complex was produced between the amino group of QDs@SiO2@MIPs and the hydroxyl group of 5-HT when 5-HT rebinding, the energy of the QDs would be transferred to the complex, which led to its fluorescence quenching. The composite material has a high selectivity with an imprinting factor of 5.96. The linear regression equation is F0/F = 0.0036Cq-0.0512, with a correlation coefficient of 0.9928 in a liner range from 50 to 500 ng/mL. The limit of detection(LOD) was 0.69 ng/mL. The probe exhibited simple preparation process, high sensitivity, good selectivity, low detection limit, short analysis time and could be applied to detect 5-HT in human serum successfully.
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