Related Experiment Video
Updated: Feb 5, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Association Between Potentially Inappropriate Medications and Frailty in the Early Old Age: A Longitudinal Study in
P Martinot1, B Landré1, M Zins2
1INSERM, U1168, VIMA: Aging and chronic diseases. Epidemiological and public health approaches, Villejuif, F-94807, France; Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, F-78180, Montigny le Bretonneux, France.
Objectives:
High-risk prescribing can have deleterious effects on the health of older people. This study aimed to assess the role of inappropriate prescribing on changes in frailty status over 3 years of follow-up.
Design, Setting:
This is a prospective observational study nested in the GAZEL cohort.
Participants:
The study sample included 12,405 community-dwelling people aged 58 to 73 in 2012, and followed for 3 years.
Measurement:
Polypharmacy and potentially inappropriate medications (PIMs) were assessed from reimbursement data by the French National Health Insurance. Frailty was evaluated each year with the Strawbridge questionnaire. PIMs were defined according to the Laroche list plus additional criteria dealing with inappropriate prolonged use of medications. The relationship between PIMs and changes in frailty status (incident frailty and recovery) was analyzed with Markov multistate modeling.
Results:
The prevalence of frailty increased from 14% in 2012 to 17% in 2014, whereas the frequency of PIMs was 29% in 2012 and 23% in 2014. Polypharmacy (5-9 drugs: aHR 1.31, 95% CI 1.14-1.50; and 10 drugs or more: aHR 1.57, 95% CI 1.28-1.92) and potentially inappropriate use of nonsteroidal anti-inflammatory drugs (aHR 1.33, 95% CI 1.04-1.71) were significantly associated with incident frailty, when the presence of at least 1 PIM presented a small association with the risk of becoming frail (aHR 1.15, 95% CI 1.01-1.32).
Conclusions/Implications:
This study brings new elements to our knowledge regarding the association between inappropriate prescribing and frailty in older adults, which support research development to alert on inappropriate prescribing and to improve drug prescribing among old people, especially with polypharmacy.
More Related Videos
Related Concept Videos
Longitudinal Studies
Longitudinal Research
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Inhaled Medications
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Associative Learning
Classical conditioning, also known...

