Related Experiment Video

Updated: Feb 5, 2026

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

1.6K

Using routine HbA1c measurements in stroke and the associations of dysglycaemia with stroke outcomes

Jeremy Lew1, Vincent Thijs2, Leonid Churilov3

  • 1Department of Endocrinology, Austin Health, Heidelberg, Vic., Australia; Department of Medicine, Austin Health, The University of Melbourne, Australia.

Journal of Diabetes and Its Complications
|September 3, 2018
PubMed

Insights

Diabetes and pre-diabetes significantly increase stroke risk and mortality. This study found that having diabetes or elevated HbA1c levels in stroke patients correlated with higher mortality and longer hospital stays, highlighting the need for better glycemic control.

Area of Science:

  • Neurology
  • Endocrinology
  • Public Health

Background:

  • Diabetes mellitus is a significant risk factor for cerebrovascular events, including stroke.
  • Understanding the prevalence of diabetes and pre-diabetes in stroke populations is crucial for risk stratification and management.

Purpose of the Study:

  • To determine the prevalence of diabetes and pre-diabetes in a cohort of stroke patients.
  • To investigate the association between glycemic status (diabetes, pre-diabetes, HbA1c levels) and outcomes such as mortality and morbidity.

Main Methods:

  • A cohort of 610 inpatients aged 54 years and older diagnosed with stroke were analyzed.
  • HbA1c levels were routinely measured. Data on length of stay, mortality (in-hospital and 6-month), readmission rates, and functional outcomes (modified Rankin scale) were collected.
  • Multivariable regression analyses were employed to assess associations.

Main Results:

  • 71% of the stroke cohort had either diabetes (31%) or pre-diabetes (40%).
  • The presence of diabetes was linked to increased odds of 6-month mortality (OR=1.90) and longer expected length of stay (IRR=1.29).
  • Elevated HbA1c levels also correlated with higher 6-month mortality (OR=1.27) and extended hospital stays (IRR=1.08).

Conclusions:

  • A high proportion of stroke patients in this cohort exhibited diabetes or pre-diabetes.
  • Both diabetes and higher HbA1c levels were significantly associated with adverse outcomes, including increased 6-month mortality and prolonged hospital stays.
  • Further investigation into the benefits of improved glycemic control for stroke outcomes is warranted.
Abstract

Keywords:
Diabetes mellitusElectronic Health RecordsHemoglobin A glycosylatedPrevalenceStroke

More Related Videos

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis06:07

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

7.7K
Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery08:14

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Published on: July 31, 2014

38.5K

Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.2K
Cardiac Output and Stroke Volume01:11

Cardiac Output and Stroke Volume

Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical cardiac...
4.9K
Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
3.4K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.9K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.3K
Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.4K