Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What are Populations and Communities?00:30

What are Populations and Communities?

37.9K
Overview
37.9K
pH Scale02:41

pH Scale

80.0K
Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
80.0K
Proteomics01:33

Proteomics

9.8K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.8K
Community Based Intervention01:30

Community Based Intervention

483
Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
483
Scaling01:26

Scaling

596
In designing and analyzing filters, resonant circuits, or circuit analysis at large, working with standard element values like 1 ohm, 1 henry, or 1 farad can be convenient before scaling these values to more realistic figures. This approach is widely utilized by not employing realistic element values in numerous examples and problems; it simplifies mastering circuit analysis through convenient component values. The complexity of calculations is thereby reduced, with the understanding that...
596
Protein Complex Assembly02:41

Protein Complex Assembly

16.8K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alkamines reveal a hidden layer of steroid and drug metabolism.

bioRxiv : the preprint server for biology·2026
Same author

Structure-centric searching enables global mapping of the public metabolome.

Nature biotechnology·2026
Same author

Enabling cross-indication protein expression analysis using a curated pan-cancer dataset and a tailored workflow.

Scientific reports·2026
Same author

Charting the Undiscovered Metabolome with Synthetic Multiplexing.

bioRxiv : the preprint server for biology·2025
Same author

The Proteomics Standards Initiative Standardized Formats for Spectral Libraries and Fragment Ion Peak Annotations: mzSpecLib and mzPAF.

Analytical chemistry·2024
Same author

plantMASST - Community-driven chemotaxonomic digitization of plants.

bioRxiv : the preprint server for biology·2024
Same journal

High-throughput DNA engineering by mating bacteria.

Cell systems·2026
Same journal

Living bacterial reservoir computers for information processing and sensing.

Cell systems·2026
Same journal

A data-driven modeling framework for mapping genotypes to synthetic microbial community functions.

Cell systems·2026
Same journal

BulkFormer: A large-scale foundation model for bulk transcriptomes.

Cell systems·2026
Same journal

Glycoform engineering of a mammalian platform to sculpt a humanized recombinant bioscavenger.

Cell systems·2026
Same journal

Targeted genomic editing of human gut Bacteroides species based on CRISPR-associated transposases.

Cell systems·2026
See all related articles

Related Experiment Video

Updated: Feb 5, 2026

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform
09:24

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Published on: June 6, 2017

9.6K

Assembling the Community-Scale Discoverable Human Proteome.

Mingxun Wang1, Jian Wang1, Jeremy Carver1

  • 1Center for Computational Mass Spectrometry and Department of Computer Science and Engineering, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.

Cell Systems
|September 3, 2018
PubMed
Summary
This summary is machine-generated.

The MassIVE Knowledge Base (MassIVE-KB) aggregates proteomics mass spectrometry data, enhancing data reusability. This open resource doubles proteome coverage and provides evidence for previously uncharacterized proteins.

Keywords:
algorithmsbig dataknowledge baseproteomicsrepositoriesspectral librariestandem mass spectrometry

More Related Videos

Coral Reef Arks: An In Situ Mesocosm and Toolkit for Assembling Reef Communities
07:59

Coral Reef Arks: An In Situ Mesocosm and Toolkit for Assembling Reef Communities

Published on: January 6, 2023

4.3K
Bioreactor Assembly for Continuous Culture of Complex Fecal Communities
09:37

Bioreactor Assembly for Continuous Culture of Complex Fecal Communities

Published on: April 25, 2025

1.2K

Related Experiment Videos

Last Updated: Feb 5, 2026

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform
09:24

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Published on: June 6, 2017

9.6K
Coral Reef Arks: An In Situ Mesocosm and Toolkit for Assembling Reef Communities
07:59

Coral Reef Arks: An In Situ Mesocosm and Toolkit for Assembling Reef Communities

Published on: January 6, 2023

4.3K
Bioreactor Assembly for Continuous Culture of Complex Fecal Communities
09:37

Bioreactor Assembly for Continuous Culture of Complex Fecal Communities

Published on: April 25, 2025

1.2K

Area of Science:

  • Proteomics
  • Bioinformatics
  • Mass Spectrometry

Background:

  • Public proteomics mass spectrometry data exceeds 31 TB across over 330,000 runs.
  • Current data aggregation lacks continuous updates and error control, limiting reusability.
  • A need exists for an open, continuously updated knowledge base with provenance.

Purpose of the Study:

  • To build the MassIVE Knowledge Base (MassIVE-KB) for aggregating proteomics mass spectrometry discoveries.
  • To provide an open, reusable data format with full provenance for community scrutiny.
  • To enhance the utility and reusability of public proteomics data.

Main Methods:

  • Aggregated >31 TB of public human mass spectrometry data from the MassIVE environment.
  • Developed MassIVE-KB to include >2.1 million precursors from 19,610 proteins.
  • Implemented strict library-scale false discovery rate controls.

Main Results:

  • MassIVE-KB is 48% larger than previous efforts, covering 97% of total identified precursors.
  • Doubled proteome coverage to 6 million amino acids (54% of the proteome).
  • Provided evidence for 430 proteins lacking sufficient prior protein-level evidence.

Conclusions:

  • MassIVE-KB significantly enhances proteome coverage and data reusability.
  • The knowledge base supports experimental design and new data identification/quantification.
  • MassIVE-KB facilitates community-driven spectral library construction.