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Related Concept Videos

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Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians.

Alessandro P Delitala1, Maristella Steri1, Edoardo Fiorillo1

  • 1Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Cagliari, Italy.

Cytokine
|September 3, 2018
PubMed
Summary

Leptin, a cytokine released by fat cells, is positively linked with thyroid-stimulating hormone (TSH) levels in euthyroid individuals. Higher adiponectin levels were also associated with thyroid autoimmunity in this study.

Keywords:
AdipocytokinesAdiponectinLeptinTSH within reference rangeThyroid autoimmunity

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Area of Science:

  • Endocrinology
  • Metabolic research
  • Immunology

Background:

  • Adipocytes release cytokines (adipocytokines) that may influence thyroid function.
  • Thyroid-stimulating hormone (TSH) regulates thyroid hormone production.
  • The interplay between adipocytokines, TSH secretion, and thyroid autoimmunity is not fully understood.

Purpose of the Study:

  • To investigate the relationship between adipocytokines and TSH levels in a general population.
  • To examine the association between adipocytokines and thyroid autoimmunity.

Main Methods:

  • A cross-sectional study was conducted on 5385 euthyroid individuals.
  • Measurements included TSH, FT4, adiponectin, leptin, and antibodies against thyroperoxidase and thyroglobulin.
  • Linear and logistic regression models were employed to analyze associations.

Main Results:

  • TSH was positively associated with leptin and negatively with age and FT4.
  • Leptin and antibodies against thyroperoxidase showed a direct association with TSH.
  • Higher adiponectin levels correlated with the presence of thyroid autoimmunity.

Conclusions:

  • Leptin may positively affect TSH secretion in euthyroid individuals, suggesting interaction within the leptin-pituitary-thyroid axis.
  • The association between adiponectin and thyroid autoimmunity warrants further investigation.