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Related Concept Videos

Unusual Results01:16

Unusual Results

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Unusual results are those that have a very low chance of occurring. Unusual results can be identified using probabilities and the range rule of thumb. In problems involving probability, unusual results can be observed in 2 instances – an unusually high number of successes or an unusually low number of successes.
According to the range rule of thumb, any value above or below two standard deviations, 2σ  from the mean, μ  is considered unusual.
Maximum unusual value =...
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z Scores and Unusual Values01:07

z Scores and Unusual Values

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The z score is one of the three measures of relative standing. It describes the location of a value in a dataset relative to the mean. z scores are obtained after the standardization of the values in a dataset. The z score for the mean is 0.
 This score indicates how far a value is from the mean in terms of standard deviation. For example, if a data value has a z score of +1, the researcher can infer that the particular data value is one standard deviation above the mean. If another data...
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Induced-fit Model01:13

Induced-fit Model

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Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Induced Electric Dipoles01:28

Induced Electric Dipoles

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A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
Since the absolute value of potential energy holds no physical meaning, its zero value can be chosen as per...
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Related Experiment Video

Updated: Feb 5, 2026

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues
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Mitotane-induced dyspnoea: an unusual side effect.

Ali U Farooq1, Waseem Amjad2, Tanureet Kochar3

  • 1Department of Cardiovascular Medicine, Charleston Area Medical Center, Charleston, South Carolina, USA.

BMJ Case Reports
|September 3, 2018
PubMed
Summary
This summary is machine-generated.

This case report details a rare instance of dyspnoea, or shortness of breath, linked to mitotane treatment for adrenocortical carcinoma. Awareness of this potential side effect is crucial for patient safety.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Mitotane is a key treatment for adrenocortical carcinoma and Cushing's syndrome.
  • Common mitotane side effects include gastrointestinal issues, cognitive changes, and hematological abnormalities.
Keywords:
adrenal disordersdrugs: respiratory systemunwanted effects / adverse reactions

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  • Dyspnoea is not a commonly recognized adverse effect of mitotane.