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Relationship Between Modic Changes and Sagittal Balance Parameters in the Cervical Spine.

Jian-Ping Wu1, Quan-Bin Wang2, Xiao-Jun Feng3

  • 1Department of Orthopaedics, People's Hospital of Yixing, Yixin, Jiangsu, China (mainland).

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Summary

A smaller Cobb angle (less than 8.5°) in the cervical spine is a potential risk factor for developing Modic changes (MCs). This finding aids in understanding MC development and associated spinal alignment.

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Area of Science:

  • Spinal Imaging and Biomechanics
  • Radiology and Diagnostic Imaging
  • Orthopedic Research

Background:

  • Modic changes (MCs) are common findings on spinal MRI.
  • The relationship between cervical sagittal parameters and MCs requires further investigation.
  • Understanding these associations can improve diagnostic and therapeutic strategies.

Purpose of the Study:

  • To investigate the association between Modic changes (MCs) and sagittal parameters of the cervical spine.
  • To identify potential risk factors for the development of cervical MCs.

Main Methods:

  • Retrospective analysis of 150 patients with cervical MCs (MC+ group) and 150 healthy controls (MC- group).
  • Measurement of cervical sagittal parameters: neck tilt (NT), T1 slope (T1s), thoracic inlet angle (TIA), and Cobb C2-C7.
  • Comparison of parameters between groups and logistic regression analysis to identify risk factors.

Main Results:

  • The Cobb C2-C7 angle was significantly smaller in the MC+ group compared to the MC- group (P<0.05).
  • No significant differences were found for NT, T1s, and TIA between the groups.
  • Logistic regression identified a Cobb C2-C7 angle less than 8.5° as a risk factor for MCs (AUC=0.82).

Conclusions:

  • A reduced Cobb C2-C7 angle (<8.5°) is a potential risk factor for the development of cervical Modic changes.
  • Cervical sagittal alignment, specifically the Cobb C2-C7 angle, plays a role in MC development.
  • Further research can explore the clinical implications of this association.