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Manufacturing nanostructured chitosan-based 2D sheets with prolonged antimicrobial activity.

Denisa Ficai1, Ioana Lavinia Ardelean, Alina Maria Holban

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Infectious Diseases

Background:

  • Chitosan hydrogels are promising for wound healing due to their biocompatibility and biodegradability.
  • Nanoparticles like silver (Ag) and zinc oxide (ZnO), along with natural compounds like usnic acid (UA), can enhance antimicrobial properties.
  • Electrospinning offers a versatile technique for creating 2D fibrous mats with controlled morphology for biomedical applications.

Purpose of the Study:

  • To synthesize and characterize chitosan-based hydrogels incorporating Ag and ZnO nanoparticles and usnic acid.
  • To evaluate the antimicrobial and antifungal activity of these composite hydrogels.
  • To develop multifunctional wound dressings with regenerative and anti-infective capabilities.

Main Methods:

  • Chitosan hydrogels were fabricated using electrospinning to create 2D sheets.
  • Composite materials were characterized using infrared (IR) spectroscopy and scanning electron microscopy (SEM).
  • Antimicrobial and antifungal activity was tested against Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.

Main Results:

  • Successful synthesis and characterization of chitosan-based hydrogels containing Ag/ZnO nanoparticles and UA.
  • Demonstrated antimicrobial activity against Gram-negative (P. aeruginosa) and Gram-positive (S. aureus) bacteria.
  • Exhibited antifungal activity against Candida albicans.

Conclusions:

  • The developed chitosan-based hydrogels show significant potential as multifunctional wound dressings.
  • The incorporation of Ag/ZnO nanoparticles and UA enhances the anti-infective properties of the hydrogels.
  • Electrospinning is an effective technique for producing advanced wound dressing materials with therapeutic benefits.