Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.7K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
Nursing Code of Ethics01:29

Nursing Code of Ethics

4.6K
The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.6K
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

4.6K
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of enhanced recovery after surgery on the rehabilitation of patients undergoing laparoscopic pancreaticoduodenectomy: A meta-analysis.

Langenbeck's archives of surgery·2026
Same author

Silver nanostructure morphology-driven surface-enhanced infrared spectroscopy for determination of deoxynivalenol in wheat flour.

Analytical methods : advancing methods and applications·2025
Same author

Prevalence, risk factors, and regional insights of bovine fasciolosis in China: A systematic review and meta-analysis.

Acta tropica·2025
Same author

Potential of mir-299-5p to modulate LPS-induced inflammation and osteogenic differentiation of periodontal stem cells by targeting PUM2.

BMC oral health·2025
Same author

[A multicenter study of neonatal stroke in Shenzhen, China].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics·2024
Same author

[Hydrochemical and Isotopic Evidence for Groundwater Conversion of Surface Water in Alpine Arid Areas: A Case Study of the Datong River Basin].

Huan jing ke xue= Huanjing kexue·2023

Related Experiment Video

Updated: Feb 5, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.2K

[Long non-coding RNAs in prostate cancer: An update].

Pin-Geng Wu1, Yu-Xi Zhang1

  • 1Department of Urology, The First Hospital Affiliated to China Medical University, Shenyang, Liaoning 110001, China.

Zhonghua Nan Ke Xue = National Journal of Andrology
|September 3, 2018
PubMed
Summary

Long non-coding RNAs (lncRNAs) are implicated in prostate cancer (PCa) development and progression. Aberrant lncRNA expression impacts PCa cell behavior, offering potential as diagnostic markers and therapeutic targets.

Keywords:
gene therapyprostate cancerregulatory mechanismtumor markerlong non-coding RNA

More Related Videos

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.2K

Related Experiment Videos

Last Updated: Feb 5, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.2K
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.2K

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts >200 nucleotides.
  • Dysregulation of lncRNAs is linked to various cancers, including prostate cancer (PCa).
  • lncRNAs play roles in epigenetic, transcriptional, and post-transcriptional gene regulation.

Purpose of the Study:

  • To review the roles and mechanisms of lncRNAs in prostate cancer.
  • To explore the clinical applications of lncRNAs in PCa diagnosis, treatment, and prognosis.
  • To highlight lncRNAs as potential biomarkers and therapeutic targets for PCa.

Main Methods:

  • Literature review of studies on lncRNAs in prostate cancer.
  • Analysis of lncRNA expression patterns in PCa tissues and biofluids.
  • Examination of lncRNA involvement in PCa progression and treatment resistance.

Main Results:

  • Abnormal lncRNA expression affects PCa cell biological behaviors.
  • Certain lncRNAs are associated with castration resistance in PCa.
  • lncRNAs are detected in various PCa samples and influence treatment response.

Conclusions:

  • lncRNAs are implicated in PCa pathogenesis and progression.
  • lncRNA expression correlates with PCa prognosis.
  • lncRNAs hold significant promise as diagnostic markers and therapeutic targets for PCa.