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Updated: Feb 5, 2026
08:16
X-ray Visualization of Intraductal Ethanol-based Ablative Infusion for Prevention of Breast Cancer in Rabbit Models
Published on: September 12, 2025
877
[NONSURGICAL ABLATION THERAPY FOR SMALL BREAST CARCINOMAS].
Nihon Geka Gakkai Zasshi
|September 3, 2018
Summary
Nonsurgical ablative therapies like radiofrequency ablation are emerging as potential replacements for lumpectomy in early-stage breast cancer treatment. Ongoing clinical trials are accumulating data on these innovative breast cancer treatments.
Area of Science:
- Oncology
- Surgical Innovation
- Medical Technology
Background:
- Breast-conserving therapy (BCT) has been a standard for early-stage breast cancer since the 1980s, with expanding indications.
- Over half of breast cancer patients currently benefit from BCT, which includes surgical removal of the tumor (lumpectomy) and often radiation or chemotherapy.
Purpose of the Study:
- To evaluate the potential of nonsurgical ablative therapies as definitive conservative treatments for early-stage breast cancer.
- To assess the accumulating data on radiofrequency ablation (RFA), cryoablation, and high-intensity focused ultrasound (HIFU) in breast cancer management.
Main Methods:
- Clinical studies initiated in 2004 for high-intensity focused ultrasound (HIFU) and 2006 for cryoablation.
- Phase I/II trials of radiofrequency ablation (RFA) began in 2006, followed by a prospective phase III trial in 2013.
- Data collection and analysis from ongoing multicenter clinical trials for these ablative techniques.
Main Results:
- Data on nonsurgical ablative therapies, including RFA, cryoablation, and HIFU, are steadily accumulating.
- These nonsurgical methods are being investigated as alternatives to traditional surgical lumpectomy for early-stage breast cancer.
Conclusions:
- Nonsurgical ablative therapies show promise as future replacements for lumpectomy in treating early-stage breast cancer.
- Continued research and data accumulation are crucial for establishing these innovative treatments as standard care.
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