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Updated: Feb 5, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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[CURRENT PERSPECTIVE ON SYSTEMIC THERAPY FOR BREAST CANCER].

Hiromitsu Jinno

    Nihon Geka Gakkai Zasshi
    |September 3, 2018
    PubMed
    Summary

    Adjuvant therapy for breast cancer, including chemotherapy and endocrine treatments like tamoxifen and aromatase inhibitors, is guided by tumor biology and stage. Multigene assays may predict chemotherapy benefit, while targeted therapies improve outcomes for specific breast cancer subtypes.

    Area of Science:

    • Oncology
    • Endocrinology
    • Genetics

    Background:

    • Adjuvant therapy decisions for breast cancer rely on tumor biology and stage.
    • Chemotherapy is generally recommended for high-risk breast cancer due to a lack of predictive factors.
    • Estrogen plays a key role in hormone receptor-positive breast cancer progression.

    Purpose of the Study:

    • To review current strategies for adjuvant therapy in breast cancer.
    • To highlight the role of chemotherapy, endocrine therapy, and targeted treatments.
    • To discuss predictive factors and treatment optimization.

    Main Methods:

    • Review of current breast cancer treatment guidelines and established therapies.
    • Analysis of the role of multigene assays in predicting chemotherapy benefit.

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  • Examination of endocrine therapy strategies including tamoxifen, luteinizing hormone-releasing hormone agonists, and aromatase inhibitors.
  • Inclusion of data on adjuvant trastuzumab for HER2-overexpressing breast cancer.

    • Main Results:

    • Multigene assays show potential in predicting chemotherapy benefit.
    • Endocrine therapy is crucial for hormone-sensitive breast cancer, with tamoxifen for premenopausal and aromatase inhibitors for postmenopausal women.
    • Extended endocrine therapy to 10 years may improve prognosis.
    • Adjuvant trastuzumab is beneficial for HER2-overexpressing breast cancer.

    Conclusions:

    • Adjuvant therapy selection is personalized based on tumor characteristics.
    • Chemotherapy, endocrine therapy, and targeted agents form the cornerstone of breast cancer treatment.
    • Ongoing research aims to refine predictive markers and optimize treatment duration for improved patient outcomes.