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Published on: November 19, 2020
Potential Prognostic, Diagnostic and Therapeutic Markers for In-stent Reocclusion in Advanced Age Patients After
Xia Li1, Fenglin Zhang1, Hualan Zhou1
1Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Background:
Oxidative stress and inflammatory response played important roles in advanced atherosclerosis. We tried to confirm clinical diagnostic significance of the assessments of oxidative stress and inflammatory response status with in-stent reocclusion in 283 advanced age patients (80~90 years) after coronary stenting.
Methods:
We analyzed levels of circulating superoxide dismutase 3 (SOD3), nitric oxide (NO), endothelial nitric oxide synthase (eNOS), malondialdehyde (MDA), acrolein(ACR), and paraoxonase-1 (PON-1)in advanced age patients with in-stent restenosis and reocclusion after coronary stenting.
Results:
Levels of SOD3, eNOS, NO and PON-1 were lowered (P<0.001) and levels of MDA and ACR were increased (P<0.001).
Conclusion:
The assessments of the biomarkers of oxidative stress and inflammatory response (levels of MDA and ACR) and anti-oxidant biomarkers (levels of eNOS, NO, SOD3 and PON-1) could be considered as potential prognostic and diagnostic indicators of in-stent reocclusion in advanced age patients after coronary stenting.
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