Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brick Durability, Strength, and Appearance01:15

Brick Durability, Strength, and Appearance

679
Brick durability, strength, and appearance are crucial factors in construction, influencing the choice of bricks for specific applications. The process of freeze-thaw, for instance, significantly affects brick durability. This phenomenon occurs when water absorbed by a brick expands as it freezes, potentially causing damage when it melts and refreezes. Bricks are graded for durability: SW-grade bricks are the most durable, offering high strength and low water absorption, followed by MW-grade...
679
What is an Experiment?01:12

What is an Experiment?

18.8K
An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
18.8K
Thomson's e/m Experiment01:19

Thomson's e/m Experiment

6.8K
In a beam of charged particles created by a heated cathode, the particles move at different speeds. However, many applications need a beam with uniform particle speeds. An arrangement known as a velocity selector uses electric and magnetic fields to pick particles with a particular speed from the beam.
A particle with charge q, speed v, and mass m enters an area from the top, where the magnetic and electric fields are perpendicular both to the particle's motion and to one another. The magnetic...
6.8K
Controls in Experiments01:13

Controls in Experiments

17.6K
When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...
17.6K
Randomized Experiments01:13

Randomized Experiments

9.1K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
9.1K
Crossover Experiments01:16

Crossover Experiments

4.6K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insights from the First Year of Program Signaling in Cardiovascular Disease Fellowship Recruitment.

Journal of the American College of Cardiology·2026
Same author

A translational model of MASLD-associated HFpEF defines mitochondrial dysfunction and cardiac plasticity during disease progression and regression.

Metabolism: clinical and experimental·2026
Same author

AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich Ataxia: A Nonrandomized Clinical Trial.

JAMA cardiology·2026
Same author

Rhodanine to Oxorhodanine Switch Switches Switching Mechanism in a Monomethine Photoswitch.

The journal of physical chemistry letters·2026
Same author

Inpatient Psychiatric Admission of a Durable Left Ventricular Assist Device Recipient: Multidisciplinary Care Plan and Policy Framework.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

Changes in Upright Hemodynamics Preceding Heart Failure Events and Other Hospitalizations.

European journal of heart failure·2026
Same journal

On the differential hemodynamic effects of prostacyclins and sotatercept.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same journal

Alveolar macrophage activation and polarization signatures in stable lung transplant recipients and chronic lung allograft dysfunction.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same journal

Distinct Metabolomic and Lipidomic Profiles Across Donation after Circulatory Death Recovery Strategies Reveal a Common Signature Associated with Primary Graft Dysfunction.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same journal

Antibody-mediated rejection after heart transplantation: diagnostic gaps, suboptimal outcomes, and emerging tools.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same journal

What sotatercept can teach us about the right ventricle in pulmonary arterial hypertension.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same journal

The Future of Heart Transplant Data Science Requires Common Data Models.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
See all related articles

Related Experiment Video

Updated: Feb 5, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

10.0K

Multicenter experience with durable biventricular assist devices.

Palak Shah1, Richard Ha2, Ramesh Singh1

  • 1Department of Heart Failure and Transplantation, Inova Heart and Vascular Institute, Falls Church, Virginia.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|September 4, 2018
PubMed
Summary
This summary is machine-generated.

Biventricular assist device (BiVAD) implantation is complex, with high mortality. Contemporaneous BiVAD implantation in experienced centers shows improved outcomes, including shorter ICU stays and better survival, compared to staged implantation.

Keywords:
biventricular assist devicecardiogenic shockheart failureright heart failureventricular assist device

More Related Videos

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.2K
Author Spotlight: Assessing Brain Activity in Robotic-Assisted Lower Limb Rehabilitation Using fNIRS
05:25

Author Spotlight: Assessing Brain Activity in Robotic-Assisted Lower Limb Rehabilitation Using fNIRS

Published on: June 7, 2024

1.8K

Related Experiment Videos

Last Updated: Feb 5, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

10.0K
In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.2K
Author Spotlight: Assessing Brain Activity in Robotic-Assisted Lower Limb Rehabilitation Using fNIRS
05:25

Author Spotlight: Assessing Brain Activity in Robotic-Assisted Lower Limb Rehabilitation Using fNIRS

Published on: June 7, 2024

1.8K

Area of Science:

  • Cardiology
  • Mechanical Circulatory Support
  • Heart Failure Management

Background:

  • Severe right ventricular failure complicates 6-11% of left ventricular assist device (LVAD) implants.
  • Durable continuous-flow biventricular assist devices (BiVADs) offer a solution for biventricular failure.
  • Limited data exists on patient outcomes with BiVADs.

Purpose of the Study:

  • To compare outcomes of contemporaneous versus staged BiVAD implantation.
  • To evaluate patient characteristics and survival rates in BiVAD recipients.
  • To assess the feasibility and efficacy of durable BiVAD support.

Main Methods:

  • Retrospective data collection from US centers with ≥ 6 BiVAD implants (2011-2017).
  • Comparison of patient characteristics and outcomes between contemporaneous and staged HVAD BiVAD implantation.
  • Analysis of operative mortality, ICU length of stay, hospital discharge, RVAD thrombosis, and survival.

Main Results:

  • 46 patients received durable BiVADs; median age 46, 80% non-ischemic cardiomyopathy, 83% bridge to transplant.
  • Operative mortality was 33%; 37% experienced RVAD thrombosis.
  • Contemporaneous BiVAD implantation (67% of cases) resulted in shorter ICU stays (12 vs 42 days) and higher discharge rates on BiVAD support (61% vs 27%).

Conclusions:

  • Durable BiVADs support critically ill patients with severe biventricular failure.
  • High operative mortality and RVAD thrombosis rates are associated with BiVADs.
  • Contemporaneous BiVAD implantation in experienced centers demonstrates promising survival rates comparable to other biventricular support strategies.