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Updated: Feb 5, 2026

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
Published on: March 1, 2022
[Liver diseases and pulmonary vascular disorders]
M Riou1, E-M Jutant2, X Mignard2
1Service de pneumologie, Nouvel hôpital civil, hôpitaux universitaires de Strasbourg, 67091 Strasbourg cedex, France.
Pulmonary vascular disorders like portopulmonary hypertension (PoPH) and hepatopulmonary syndrome (HPS) affect liver transplant candidates. Liver transplantation is key for HPS and may benefit selected PoPH patients.
Area of Science:
- Cardiology
- Pulmonology
- Hepatology
- Transplantation Medicine
Background:
- Dyspnea affects approximately 70% of patients awaiting liver transplantation.
- Portal hypertension and chronic liver diseases are associated with two main pulmonary vascular disorders: portopulmonary hypertension (PoPH) and hepatopulmonary syndrome (HPS).
Purpose of the Study:
- To review the pathophysiology, diagnostic criteria, and management of PoPH and HPS in patients with portal hypertension.
- To discuss the role of liver transplantation in the management of HPS and selected PoPH cases.
Main Methods:
- Literature review of PoPH and HPS in patients with portal hypertension.
- Analysis of diagnostic criteria including pulmonary arterial hypertension (PAH), pulmonary artery pressure (PAP), and pulmonary vascular resistance (PVR).
Main Results:
- PoPH involves pulmonary small artery remodeling and obstruction, defined by PAH with portal hypertension.
- HPS is characterized by intrapulmonary vascular dilatations and hypoxemia.
- Both conditions negatively impact prognosis, with liver transplantation being the standard for HPS and a potential option for selected PoPH patients.
Conclusions:
- Liver transplantation is the established treatment for HPS.
- Selected PoPH patients may benefit from liver transplantation, particularly those with specific hemodynamic profiles.
- Further research is needed to fully understand the complex pathophysiology of these syndromes.
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