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Updated: Feb 5, 2026

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
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Published on: September 5, 2017

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Use of idarucizumab in reversing dabigatran anticoagulant effect: a critical appraisal

Marco Proietti1,2,3, Giuseppe Boriani4

  • 1Department of Neuroscience, I Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.

Therapeutics and Clinical Risk Management
|September 4, 2018
PubMed

Use of non-vitamin K antagonist oral anticoagulants is spreading in the real world. Despite that, a strong need for antidotes/reversal agents is still reported by several physicians. Idarucizumab is a humanized monoclonal antibody fragment that binds specifically to dabigatran. Idarucizumab was approved in 2015 by the US Food and Drugs Administration and European Medicines Agency for reversal of anticoagulation activity in dabigatrantreated patients. This review briefly summarizes the experimental evidence about effectiveness and safety of idarucizumab. Furthermore, we review the current recommendations and experts' point of view about the use of antidotes/reversal agents in patients reporting a major bleeding event.

Keywords:
anticoagulant drugsidarucizumabmajor bleedingnon-vitamin K antagonist oral anticoagulantsreversal agents

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