Tissue expansion in burn sequelae has been associated with high complication rates. A critical analysis of 8 years (2008-2015) of experience with 45 expanders placed in 31 consecutive burns sequelae was performed to identify those factors that predispose to complications. Major and minor complications occurred in 33.4% of procedures. The factor associated with a statistically significant increase in complications was limbs localization. In addition, complications were significantly more likely to occur within the second stage. Factors that did not influence complication rate included patient age, the volume of the expander, and aesthetic or functional indications.