Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is an Experiment?01:12

What is an Experiment?

18.8K
An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
18.8K
Autophagic Cell Death01:18

Autophagic Cell Death

4.6K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.6K
Overview of Cell Death01:30

Overview of Cell Death

10.1K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
10.1K
Thomson's e/m Experiment01:19

Thomson's e/m Experiment

6.8K
In a beam of charged particles created by a heated cathode, the particles move at different speeds. However, many applications need a beam with uniform particle speeds. An arrangement known as a velocity selector uses electric and magnetic fields to pick particles with a particular speed from the beam.
A particle with charge q, speed v, and mass m enters an area from the top, where the magnetic and electric fields are perpendicular both to the particle's motion and to one another. The magnetic...
6.8K
Controls in Experiments01:13

Controls in Experiments

17.6K
When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...
17.6K
Randomized Experiments01:13

Randomized Experiments

9.1K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reorganization of Human Brain Waves Across Diverse States of Consciousness.

bioRxiv : the preprint server for biology·2026
Same author

Computational spirits: a neuroscientific account of psychedelic entity encounters.

Neuroscience of consciousness·2026
Same author

The goal of specificity in psychotropic drug development: A lesson from Sisyphus?

Journal of psychopharmacology (Oxford, England)·2026
Same author

Autonomic indicators of self-transcendence: insights from the numadelic VR paradigm.

Neuroscience of consciousness·2026
Same author

An international mega-analysis of psychedelic drug effects on brain circuit function.

Nature medicine·2026
Same author

How to set up a psychedelic study: Unique considerations for research involving human participants.

Neuroscience and biobehavioral reviews·2026
Same journal

From silenced shock to strategic resilience: a longitudinal qualitative study of nurse residents' trajectory in coping with patient verbal abuse.

Frontiers in psychology·2026
Same journal

Validation of the Internet Addiction Test (IAT) for forest firefighters: implications for human-technology interaction and occupational safety in the future of work.

Frontiers in psychology·2026
Same journal

Development and validation of the football emotion scale for Chinese youth players: a psychometric study.

Frontiers in psychology·2026
Same journal

From online engagement to offline action: how social media environmental engagement shapes university students' pro-environmental citizenship through intrinsic motivation and personal norms.

Frontiers in psychology·2026
Same journal

The multidimensional inventory of religious/spiritual wellbeing in Hungarian language: psychometric properties and initial validation.

Frontiers in psychology·2026
Same journal

Effects of occupational factors on depression in Chinese veterans: a fsQCA study based on 2022 CFPS data.

Frontiers in psychology·2026
See all related articles

Related Experiment Video

Updated: Feb 5, 2026

Pre-clinical Model of Cardiac Donation after Circulatory Death
06:26

Pre-clinical Model of Cardiac Donation after Circulatory Death

Published on: August 2, 2019

8.4K

DMT Models the Near-Death Experience.

Christopher Timmermann1,2, Leor Roseman1,2, Luke Williams1

  • 1Psychedelic Research Group, Centre for Psychiatry, Department of Medicine, Imperial College London, London, United Kingdom.

Frontiers in Psychology
|September 4, 2018
PubMed
Summary
This summary is machine-generated.

This study found that N,N-Dimethyltryptamine (DMT) administration significantly increased near-death experience (NDE) features in healthy participants. The DMT state closely mirrored the phenomenology of actual NDEs, suggesting a shared underlying mechanism.

Keywords:
DMTNN-DimethyltryptamineNDEabsorptiondelusional ideationnear-death experiencephenomenologypsychedelic

More Related Videos

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
07:08

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

675
Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
10:36

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

Published on: November 6, 2017

8.5K

Related Experiment Videos

Last Updated: Feb 5, 2026

Pre-clinical Model of Cardiac Donation after Circulatory Death
06:26

Pre-clinical Model of Cardiac Donation after Circulatory Death

Published on: August 2, 2019

8.4K
A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
07:08

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

675
Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
10:36

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

Published on: November 6, 2017

8.5K

Area of Science:

  • Neuroscience
  • Psychology
  • Pharmacology

Background:

  • Near-death experiences (NDEs) share phenomenological similarities with psychedelic states, particularly those induced by N,N-Dimethyltryptamine (DMT).
  • These similarities include out-of-body sensations, encounters with entities, and themes of death and dying.

Purpose of the Study:

  • To investigate the phenomenological overlap between DMT-induced experiences and NDEs.
  • To compare the subjective effects of DMT with validated NDE measures.

Main Methods:

  • A within-subjects, placebo-controlled study administering DMT to 13 healthy participants.
  • Participants completed a validated NDE questionnaire after receiving DMT or placebo.
  • Correlations were analyzed between NDE scores, DMT-induced experiences (ego-dissolution, mystical-type), and baseline traits (absorption, delusional ideation).

Main Results:

  • DMT administration significantly increased NDE-associated features compared to placebo.
  • NDE scores correlated with DMT-induced ego-dissolution, mystical experiences, baseline absorption, and delusional ideation.
  • A significant overlap was observed in almost all NDE phenomenological features between DMT-induced and actual NDEs.

Conclusions:

  • The findings reveal a striking similarity between DMT-induced states and NDEs.
  • This suggests a potential common neurobiological or psychological basis for these profound experiences.
  • Further research is warranted to explore the mechanisms underlying these shared phenomena.