Related Experiment Video
Updated: Feb 5, 2026
08:22
Orthotopic Left Lung Transplantation in Rats
Published on: July 3, 2025
755
Lung transplantation: indications and contraindications
1Weill Consulting Group, New Orleans, LA, USA.
Journal of Thoracic Disease
|September 4, 2018
Summary
Selecting lung transplant recipients is evolving, with guidelines updated over decades. Individual centers must weigh evidence to determine candidate suitability due to limited data in some areas.
Area of Science:
- Cardiology and Thoracic Surgery
- Transplantation Medicine
Background:
- Lung transplantation recipient selection criteria have evolved significantly over recent decades.
- The International Society for Heart and Lung Transplantation (ISHLT) has published three editions of recipient selection guidelines (1998, 2006, 2015).
- There is a notable scarcity of robust scientific data in many aspects of recipient selection.
Purpose of the Study:
- To review the evolution of lung transplant recipient selection criteria.
- To discuss areas with strong scientific evidence and acknowledge data limitations.
- To emphasize the role of individual transplant centers in final candidate determination.
Main Methods:
- Review of historical recipient selection guidelines from the ISHLT.
- Analysis of available scientific literature regarding indications and contraindications.
- Discussion of the decision-making process for patient suitability.
Main Results:
- Recipient selection for lung transplantation is a dynamic field influenced by growing experience.
- Guidelines have been progressively updated, reflecting advancements in the field.
- Many aspects of selection rely on expert judgment due to insufficient empirical data.
Conclusions:
- Individual transplant centers hold the ultimate responsibility for determining recipient eligibility.
- Careful consideration of available evidence is crucial for appropriate candidate selection.
- Timely referral and listing of patients with advanced lung disease are important considerations.
Related Concept Videos
02:39Indicators
61.0K
Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
61.0K
01:47Lung Capacity
56.4K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
01:29Mechanical Ventilation I: Indication and Settings
2.9K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
2.9K
01:19Respiratory Assessment: Purpose and Indications
1.8K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.8K
01:09Bioequivalence of Drugs: Drugs with Multiple Indications
162
The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
162
01:18Cardiovascular Drugs: Classification based on Therapeutic Indications
4.2K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.2K