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Related Concept Videos

Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cell Migration01:09

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Cancer Cell Migration through Invadopodia01:35

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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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Chemotaxis and Direction of Cell Migration01:21

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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
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Role of Myosin in Cell Migration01:18

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Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
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Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Related Experiment Video

Updated: Feb 5, 2026

Zebrafish Keratocyte Explants to Study Collective Cell Migration and Reepithelialization in Cutaneous Wound Healing
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Using Zebrafish to Study Collective Cell Migration in Development and Disease.

Hannah M Olson1,2, Alex V Nechiporuk1

  • 1Department Cell, Developmental & Cancer Biology, The Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States.

Frontiers in Cell and Developmental Biology
|September 4, 2018
PubMed
Summary

Collective cell migration is vital for development and health. Zebrafish posterior lateral line primordium (pLLP) migration offers a powerful model to study these coordinated cell movements and their role in disease.

Keywords:
cancercollective cell invasioncollective cell migrationposterior lateral lineposterior lateral line primordium

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Analyzing In Vivo Cell Migration using Cell Transplantations and Time-lapse Imaging in Zebrafish Embryos
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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Cancer Research

Background:

  • Cellular migration is crucial for embryonic development and adult tissue maintenance.
  • Collective cell migration involves coordinated cell behavior, essential for processes like development and wound healing.
  • Dysregulated collective cell migration is implicated in cancer invasion.

Purpose of the Study:

  • To review the cellular behaviors and signaling mechanisms of the zebrafish posterior lateral line primordium (pLLP) in collective cell migration.
  • To compare collective cell migration in the pLLP model with other established systems.
  • To explore the hijacking of collective cell migration by invading cancer cells.

Main Methods:

  • Utilizes zebrafish as a genetic model system for in vivo visualization and manipulation.
  • Examines the posterior lateral line primordium (pLLP), a cohort of approximately 100 cells.
  • Compares findings with other model systems such as Drosophila, chick, and Xenopus.

Main Results:

  • The zebrafish pLLP system allows for easy in vivo visualization and genetic manipulation due to embryo transparency and superficial migration.
  • The pLLP deposits cell clusters that differentiate into mechanosensory organs.
  • Collective cell migration mechanisms in the pLLP provide insights into both normal development and pathological processes like cancer metastasis.

Conclusions:

  • The zebrafish pLLP is a premier model for studying collective cell migration due to its experimental advantages.
  • Understanding collective cell migration in models like the pLLP can illuminate mechanisms of developmental processes and cancer invasion.
  • Further research in this model can advance our knowledge of cell coordination and disease.