Related Experiment Video
Updated: Feb 5, 2026
18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
Published on: January 11, 2020
Urinary Fluoride Excretion after a Single Application of Fluoride Varnish in Preschool Children
Insights
Topical fluoride varnish did not significantly increase urinary fluoride excretion in preschool children using fluoride toothpaste. This study found no significant difference compared to placebo, indicating minimal systemic absorption from a single application.
Area of Science:
- Pediatric Dentistry
- Preventive Dentistry
- Fluoride Toxicology
Background:
- Fluoride varnishes are widely used for caries prevention in children.
- Assessing systemic fluoride absorption is crucial for understanding safety profiles.
Purpose of the Study:
- To evaluate urinary fluoride excretion following a single topical application of a commercial fluoride varnish in preschool children.
- To compare fluoride excretion between active varnish and placebo.
Main Methods:
- A placebo-controlled, cross-over trial involving 12 healthy preschool children (2.5-6.0 years).
- Urine samples collected at baseline and for 6 hours post-application of 7,700 ppm F varnish or placebo.
- Fluoride levels measured using an ion-sensitive electrode, with concurrent use of fluoride toothpaste supervised.
Main Results:
- One participant was excluded due to non-compliance.
- Mean urinary fluoride levels were slightly higher after active varnish but not statistically significant compared to placebo.
- No significant differences in fluoride excretion were observed compared to baseline for either varnish.
Conclusions:
- A single topical application of the tested fluoride varnish did not significantly increase urinary fluoride excretion in preschool children using fluoride toothpaste.
- The findings suggest minimal systemic fluoride absorption from this specific varnish under the study conditions.
Purpose:
To assess urinary fluoride excretion after topical application of a commercial fluoride varnish in preschool children.
Materials And Methods:
Twelve healthy children, 2.5-6.0 years of age, were enrolled in a placebo-controlled cross-over trial. After a 5-day run-in period, the morning urine was collected as baseline. One hour after breakfast, 0.1 ml of the active (Fluor Protector S; 7,700 ppm F) or the placebo varnish was applied with a microbrush on the buccal surfaces of the primary teeth. Thereafter, a 6-h urine sample was collected and the fluoride content was determined with an ion-sensitive electrode. The parents supervised toothbrushing with a small-fingernail amount of fluoride toothpaste (1000 ppm) twice daily during the entire experiment.
Results:
One boy failed to comply with the urinary samplings and was excluded. The mean fluoride concentration in the 6-h urine samples was slightly higher after the active varnish compared with the placebo varnish, but the difference was not statistically significant. Likewise, no statistically significant differences were obtained when the post-treatment concentrations were compared with baseline for the two varnishes. No side-effects or adverse events were reported.
Conclusion:
A single topical treatment with the investigated varnish did not significantly increase the urinary fluoride excretion compared with placebo in preschool children with parallel use of fluoride toothpaste.
Related Concept Videos
01:11One-Compartment Open Model: Urinary Excretion Data and Determination of k
02:12What Are Osmoregulation and Excretion?
01:15Renal Drug Excretion: Overview
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
01:13Introduction to Urinary System
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
01:23Urinary Bladder
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
01:20Disorders of the Urinary System
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...