Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Normal Distribution01:11

Normal Distribution

17.2K
The normal, a continuous distribution, is the most important of all the distributions. Its graph is a bell-shaped symmetrical curve, which is observed in almost all disciplines. Some of these include psychology, business, economics, the sciences, nursing, and, of course, mathematics. Some instructors may use the normal distribution to help determine students’ grades. Most IQ scores are normally distributed. Often real-estate prices fit a normal distribution. The normal distribution is...
17.2K
Normal Stress01:19

Normal Stress

1.4K
Normal stress is a type of stress that occurs when forces act perpendicular, or normal, to a material's cross-sectional area. This stress often arises in structures when subjected to axial loading, which is the application of force along the axis of an object. A practical example of this can be found in bridge truss members.
When a rod is under axial loading, the internal forces and corresponding stress are normal to the plane of the section, so it is termed normal stress. It's important to...
1.4K
Force Classification01:22

Force Classification

2.4K
Forces play a crucial role in the study of physics and engineering. They are essential in describing the motion, behavior, and equilibrium of objects in the physical world. Forces can be classified based on their origin, type, and direction of action.
Contact and non-contact forces are two of the most widely used categories of forces. As the name suggests, contact forces require physical contact between two objects to act upon each other. Examples of contact forces include frictional,...
2.4K
Classification of Neurotransmitters01:30

Classification of Neurotransmitters

5.3K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
5.3K
Classification of Leukocytes01:30

Classification of Leukocytes

5.9K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
5.9K
Classification of Illness01:17

Classification of Illness

8.8K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
8.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tarin-Loaded Nanoliposomes Activate Apoptosis and Autophagy and Inhibit the Migration of Human Mammary Adenocarcinoma Cells.

International journal of nanomedicine·2023
Same author

Allergen extraction: Factors influencing immunogenicity and sensitivity of immunoassays.

Journal of immunological methods·2021
Same author

Induction of food tolerance is dependent on intestinal inflammatory state.

Immunology letters·2021
Same author

Taro Lectin Can Act as a Cytokine-Mimetic Compound, Stimulating Myeloid and T Lymphocyte Lineages and Protecting Progenitors in Murine Bone Marrow.

Pharmaceutics·2021
Same author

Anticancer and Immunomodulatory Benefits of Taro (<i>Colocasia esculenta)</i> Corms, an Underexploited Tuber Crop.

International journal of molecular sciences·2021
Same author

Comparison of two techniques for a comprehensive gut histopathological analysis: Swiss Roll versus Intestine Strips.

Experimental and molecular pathology·2019

Related Experiment Video

Updated: Feb 5, 2026

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

13.3K

A histomorphometric classification system for normal and inflamed mouse duodenum-Quali-quantitative approach.

Airton Pereira E Silva1,2, João R A Soares1,3, Erika Bertozzi de Aquino Mattos1,2

  • 1Gastrointestinal Immunology Group, Department of Immunobiology, Institute of Biology, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.

International Journal of Experimental Pathology
|September 4, 2018
PubMed
Summary

Researchers developed a new classification system for mouse small intestinal histomorphology to improve experimental consistency. This system aids in comparing models of gut inflammation, crucial for understanding conditions like food allergy and inflammatory bowel disease.

Keywords:
food allergygut inflammationinflammation scoremouse

More Related Videos

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

11.3K
Laparoscopic Duodenum-Preserving Pancreatic Head Resection via Inferior Infracolic Approach: A Surgical Approach for Benign Lesions
03:34

Laparoscopic Duodenum-Preserving Pancreatic Head Resection via Inferior Infracolic Approach: A Surgical Approach for Benign Lesions

Published on: February 9, 2024

913

Related Experiment Videos

Last Updated: Feb 5, 2026

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

13.3K
Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

11.3K
Laparoscopic Duodenum-Preserving Pancreatic Head Resection via Inferior Infracolic Approach: A Surgical Approach for Benign Lesions
03:34

Laparoscopic Duodenum-Preserving Pancreatic Head Resection via Inferior Infracolic Approach: A Surgical Approach for Benign Lesions

Published on: February 9, 2024

913

Area of Science:

  • Immunology
  • Gastroenterology
  • Histopathology

Background:

  • The gut-associated lymphoid tissue maintains homeostasis through mucosal tolerance.
  • Inflammatory responses to gut antigens can lead to diseases like food allergy and inflammatory bowel disease.
  • Current experimental models lack a standardized classification system for intestinal histomorphology.

Purpose of the Study:

  • To propose a classification system for small intestinal histomorphology in experimental mice.
  • To enable more consistent comparisons between different experimental models of gut inflammation.

Main Methods:

  • Utilized a mouse model of antigen-specific gut inflammation.
  • Analyzed duodenum sections stained with hematoxylin-eosin and Alcian blue.
  • Quantified parameters including villus dimensions, enterocyte counts, immune cell infiltration, and goblet cell counts.

Main Results:

  • Developed a classification system based on histomorphological changes.
  • Observed time-dependent shortening and widening of villi in sensitized mice challenged with allergens.
  • Identified leukocyte infiltrate and goblet cell loss as key indicators of inflammation.

Conclusions:

  • The proposed classification system standardizes the assessment of experimental intestinal inflammation in mice.
  • This system facilitates improved comparability of research findings across studies.
  • It provides a framework for better understanding gut immune responses and associated pathologies.