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Growth differentiation factor-15 is a predictive biomarker in primary ventricular fibrillation: The RUTI-STEMI-PVF

C Garcia-Garcia1,2, F Rueda1,3, J Lupon1,3

  • 1Heart Institute, Hospital Universitari Germans Trias i Pujol, Spain.

European Heart Journal. Acute Cardiovascular Care
|September 4, 2018
PubMed
Summary
This summary is machine-generated.

Growth differentiation factor-15 (GDF-15) predicts mortality in ST-segment elevation myocardial infarction (STEMI) patients experiencing primary ventricular fibrillation. Higher GDF-15 levels indicate increased risk, aiding in risk stratification for STEMI complications.

Keywords:
Growth differentiation factor-15ST-segment elevation myocardial infarction prognosisprimary ventricular fibrillation

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Area of Science:

  • Cardiology
  • Biomarkers
  • Myocardial Infarction Research

Background:

  • Primary ventricular fibrillation (VF) is a serious complication of ST-segment elevation myocardial infarction (STEMI).
  • Current biomarkers for predicting VF risk in STEMI patients are insufficient.
  • Growth differentiation factor-15 (GDF-15) is a known marker for inflammation, oxidative stress, and hypoxia with prognostic value in STEMI.

Purpose of the Study:

  • To investigate the predictive value of Growth differentiation factor-15 (GDF-15) in STEMI patients who develop primary ventricular fibrillation.
  • To assess GDF-15 as a biomarker for mortality risk in this specific patient subgroup.

Main Methods:

  • Prospective registry analysis of STEMI patients treated with primary percutaneous coronary intervention (PCI) between February 2011 and August 2015.
  • Measurement of Growth differentiation factor-15 (GDF-15) concentrations upon patient admission.
  • Application of logistic regression and Cox proportional regression analyses for statistical evaluation.

Main Results:

  • The study included 1165 STEMI patients, with 72 (6.2%) experiencing primary VF.
  • STEMI patients with primary VF had significantly higher median GDF-15 levels (2655 pg/ml) compared to those without VF (1367 pg/ml; p<0.001).
  • GDF-15 independently predicted 30-day mortality in STEMI patients with primary VF (OR 3.92) and without VF (OR 1.72), even after multivariable adjustment.

Conclusions:

  • Growth differentiation factor-15 (GDF-15) is a robust and independent predictor of 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients.
  • This finding is particularly significant for STEMI patients who develop primary ventricular fibrillation, highlighting GDF-15's role in risk stratification.