Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

38.1K
The Concept of Multiple Allelism
38.1K
Lethal Alleles02:41

Lethal Alleles

18.1K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
18.1K
Disorders of Leukocytes01:27

Disorders of Leukocytes

2.0K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.0K
Classification of Leukocytes01:30

Classification of Leukocytes

5.9K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
5.9K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

18.4K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.4K
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

734
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
734

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nitrification potential and ammonia-oxidizing archaeal diversity in three contrasting acidic soils of eastern China.

Environmental research·2026
Same author

Mechanism of action of alkaloids in <i>Fritillaria</i>-induced autophagy and apoptosis in non-small cell lung cancer.

Oncology letters·2026
Same author

Neoadjuvant ALK tyrosine kinase inhibitor in patients with resectable locally advanced non-small cell lung cancer harboring <i>ALK</i> rearrangement.

Translational lung cancer research·2026
Same author

Impact of pleural lavage fluid volume on perioperative outcomes in non-small cell lung cancer patients undergoing video-assisted thoracoscopic lobectomy: a randomized controlled trial.

Translational lung cancer research·2026
Same author

Effect of Surgical Resection on Isolated Pleural Dissemination in Patients with Stage IV (M1a) Non-Small Cell Lung Cancer: Analysis from a Cohort-Based Registry and a Population-Based Database.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same author

A Prospective, Multicenter, Single-Arm Study to Evaluate the Efficacy and Safety of Augmented Reality Navigation-Guided Pulmonary Nodule Localization System.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026

Related Experiment Video

Updated: Feb 5, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

10.6K

Human leukocyte antigen (HLA)-DRB1 allele polymorphisms and systemic sclerosis.

Yanzhen Xu1,2, Nanfang Mo2, Zhiwen Jiang2

  • 1Department of Pathophysiology, Guangxi Medical University, Nanning, Guangxi, China.

Modern Rheumatology
|September 4, 2018
PubMed
Summary

Certain human leukocyte antigen (HLA) alleles, specifically DRB1*04:03, DRB1*08, DRB1*11, and DRB1*11:04, are linked to an increased risk of systemic sclerosis (SSc). Other HLA-DRB1 alleles show a protective effect in specific populations.

Keywords:
ATAHLA-DRB1SScanti-topoisomerase 1 antibodymeta-analysispolymorphismssystemic sclerosis

More Related Videos

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
08:27

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

15.3K
HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
07:18

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL

Published on: April 11, 2011

15.9K

Related Experiment Videos

Last Updated: Feb 5, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

10.6K
Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
08:27

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

15.3K
HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
07:18

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL

Published on: April 11, 2011

15.9K

Area of Science:

  • Immunogenetics
  • Rheumatology
  • Human Leukocyte Antigen (HLA) research

Background:

  • Human leukocyte antigen (HLA) genes are crucial for immune regulation.
  • Previous studies on the association between HLA-DRB1 allele polymorphisms and systemic sclerosis (SSc) have yielded controversial results.
  • A comprehensive meta-analysis is needed to clarify these associations.

Purpose of the Study:

  • To perform a meta-analysis assessing the association between HLA-DRB1 alleles and the risk of developing systemic sclerosis (SSc).
  • To investigate the relationship between specific SSc-related autoantibodies and HLA-DRB1 alleles.

Main Methods:

  • Systematic search of electronic databases for relevant case-control studies.
  • Inclusion of 11 case-control studies comprising 3268 SSc cases and 5548 controls.
  • Utilized odds ratios (ORs) and 95% confidence intervals to evaluate the strength of associations.

Main Results:

  • Four HLA-DRB1 alleles (DRB1*04:03, DRB1*08, DRB1*11, DRB1*11:04) were associated with an increased risk of SSc.
  • Five alleles (DRB1*07, DRB1*11:01, DRB1*13, DRB1*13:01, DRB1*14) demonstrated a protective effect.
  • Specific alleles showed ethnic variations in risk and protection; DRB1*11:04 was linked to higher SSc risk in Caucasians, while DRB1*13:02 was protective in Asians.
  • DRB1*11:04 was more frequent in ATA-positive SSc patients.

Conclusions:

  • The HLA-DRB1 alleles DRB1*04:03, DRB1*08, DRB1*11, and DRB1*11:04 are significantly associated with an increased risk of systemic sclerosis.
  • HLA-DRB1*11 and DRB1*11:04 are also associated with anti-tissue antibody (ATA) status in SSc patients.