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Bioequivalence Data: Statistical Interpretation01:16

Bioequivalence Data: Statistical Interpretation

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Body:The statistical interpretation of bioequivalence data is a significant aspect of pharmaceutical research. Bioequivalence refers to the absence of any significant difference in the rate and extent to which the active ingredient in pharmaceutical products becomes available at the site of drug action when administered at the same molar dose under similar conditions. This helps determine if different drug products have similar absorption rates, ensuring their interchangeability.Statistical...
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Group 1 elements are soft and shiny metallic solids. They are malleable, ductile, and good conductors of heat and electricity. The melting points of the alkali metals are unusually low for metals and decrease going down the group, while the density increases going down the group with the exception of potassium (Table 1).
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Determining the Chemical Composition of Corrosion Inhibitor/Metal Interfaces with XPS: Minimizing Post Immersion Oxidation
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Interpreting Atom Probe Data from Oxide-Metal Interfaces.

Ingrid McCarroll1, Barbara Scherrer2, Peter Felfer3

  • 11School of Aerospace Mechanical and Mechatronic Engineering,The University of Sydney,Sydney,NSW 2006,Australia.

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
|September 4, 2018
PubMed
Summary
This summary is machine-generated.

Understanding oxide-metal interfaces is critical for advanced materials. This study investigates trajectory artifacts in atom probe tomography, aiming to improve interface analysis by understanding local evaporation fields.

Keywords:
atom probe tomography/APThigh field evaporationinterface analysisreconstruction

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Area of Science:

  • Materials Science
  • Surface Science
  • Analytical Chemistry

Background:

  • Oxide-metal interfaces are vital for semiconductor devices and power generation.
  • Atom probe tomography (APT) offers 3D atomic-scale chemical composition analysis.
  • Interfacial analysis using APT is challenged by trajectory aberrations and reconstruction artifacts.

Purpose of the Study:

  • To investigate trajectory artifacts in atom probe tomography.
  • To understand the role of local evaporation field conditions in these artifacts.
  • To provide insights for improving APT reconstruction of interfaces.

Main Methods:

  • Correlative microscopy and field simulation techniques were employed.
  • The study focused on analyzing local evaporation field conditions.
  • Investigated nonuniform tip geometry evolution during field evaporation.

Main Results:

  • Heterogeneous field evaporation leads to nonuniform tip evolution.
  • This nonuniform evolution is a significant contributor to trajectory aberrations.
  • Local magnification and reconstruction artifacts are linked to these field conditions.

Conclusions:

  • A deeper understanding of local evaporation fields is key to addressing APT artifacts.
  • This knowledge may enable correction of local magnification effects during reconstruction.
  • Improved APT analysis of oxide-metal interfaces is a potential outcome.