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Published on: June 4, 2020
Unravelling the hip pistol grip/cam deformity: Origins to joint degeneration
Paul E Beaulé1, George Grammatopoulos1, Andrew Speirs2
1The Ottawa Hospital, 501 Smyth Road, Ottawa, Ontario, K1H 8L6.
Insights
Cam morphology, a hip deformity, is a significant cause of early hip osteoarthritis (OA) in some individuals. This 9-year study confirms the link and suggests interventions to prevent degeneration.
Area of Science:
- Orthopaedic Surgery
- Radiology
- Biomechanical Engineering
Background:
- Preexisting abnormal hip morphology is a risk factor for early hip osteoarthritis (OA).
- Cam morphology, a type of femoroacetabular impingement, is implicated in hip degeneration.
Purpose of the Study:
- To investigate the causal relationship between cam morphology and the development of hip OA.
- To establish temporality, biological plausibility, and specificity of cam morphology as a cause of OA.
Main Methods:
- Review of 9 years of research, including pediatric population studies.
- In silico (finite element analysis) and in vivo (imaging biomarkers) investigations.
- Assessment of Hill's criteria to determine causality.
Main Results:
- A strong association was found between cam morphology, reduced range of motion, hip pain, and cartilage degeneration.
- Temporality was established, with cam morphology preceding joint degeneration.
- Biological plausibility and gradient were demonstrated, linking deformity degree to damage extent.
Conclusions:
- Cam morphology is a cause of hip OA in susceptible individuals.
- Interventions to remove cam morphology can positively influence the degenerative process.
- Recommendations for screening, follow-up, and patient-specific assessment are proposed to prevent early joint degeneration.
Abstract:
This article reviews a body of work performed by the investigators over 9 years that has addressed the significance of cam morphology in the development of hip osteoarthritis (OA). Early hip joint degeneration is a common clinical presentation and preexisting abnormal joint morphology is a risk factor for its development. Interrogating Hill's criteria, we tested whether cam-type femoroacetabular impingement leads to hip OA. Strength of association was identified between cam morphology, reduced range-of-movement, hip pain, and cartilage degeneration. By studying a pediatric population, we were able to characterize the temporality between cam morphology (occurring 1st) and joint degeneration. Using in silico (finite element) and in vivo (imaging biomarkers) studies, we demonstrated the biological plausibility of how a cam deformity can lead to joint degeneration. Furthermore, we were able to show a biological gradient between degree of cam deformity and extent of articular damage. However, not all patients develop joint degeneration and we were able to characterize which factors contribute to this (specificity). Lastly, we were able to show that by removing the cam morphology, one could positively influence the degenerative process (experiment). The findings of this body of work show consistency and coherence with the literature. Furthermore, they illustrate how cam morphology can lead to early joint degeneration analogous to SCFE, dysplasia, and joint mal-reduction post-injury. The findings of this study open new avenues on the association between cam morphology and OA including recommendations for the study, screening, follow-up, and assessment (patient-specific) of individuals with cam morphology in order to prevent early joint degeneration. Statement of significance: By satisfying Hill's criteria, one can deduct that in some individuals, cam morphology is a cause of OA. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:3125-3135, 2018.
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