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[Omalizumab in children with uncontrolled asthma: a real-life study carried out in Colombia]

Olga Morales-Múnera1, Ángela Pedraza, Laura Niño-Serna

  • 1Hospital San Vicente Fundación, Departamento de Pediatría, Medellín, Colombia. lavusnino@gmail.com.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|September 4, 2018
PubMed

Insights

Omalizumab significantly improved asthma symptoms in children over 6 years old in real-world use. This add-on therapy reduced controller medication needs and corticosteroid dosages, demonstrating its effectiveness and safety.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Pharmacology

Background:

  • Controlled trials confirm omalizumab's efficacy and safety in children over 6 with asthma.
  • Limited real-world studies exist for this demographic.

Purpose of the Study:

  • To evaluate omalizumab's effectiveness as an add-on therapy for moderate to severe persistent asthma in children under real-life conditions.
  • To assess symptom response and changes in medication use.

Main Methods:

  • An observational study with 12-month real-life follow-up.
  • 61 children over 6 years old with moderate to severe persistent asthma were assessed.
  • Asthma control was evaluated before treatment and at 4 and 12 months.

Main Results:

  • Significant symptom improvement observed after 12 months of omalizumab treatment (p = 0.001).
  • Controller drug consumption decreased in 73% of patients; inhaled corticosteroid doses were reduced in 61% and discontinued in 8%.
  • Average inhaled corticosteroid dose significantly decreased (p = 0.02).

Conclusions:

  • Omalizumab is an effective, safe, and well-tolerated add-on therapy for achieving clinical control in moderate to severe allergic asthma.
  • It provides significant benefits for children whose asthma is not adequately managed by standard therapies.
Abstract

Keywords:
AdolescentAsthmaChildObservational studyOmalizumab

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