Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

3.6K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
3.6K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

9.3K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
9.3K
Van der Waals Interactions01:24

Van der Waals Interactions

71.6K
Atoms and molecules interact with each other through intermolecular forces. These electrostatic forces arise from attractive or repulsive interactions between particles with permanent, partial, or temporary charges. The intermolecular forces between neutral atoms and molecules are ion–dipole, dipole–dipole, and dispersion forces, collectively known as van der Waals forces.
71.6K
Eukaryotic Transcription Activators02:42

Eukaryotic Transcription Activators

12.8K
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These...
12.8K
Predator-Prey Interactions02:39

Predator-Prey Interactions

21.7K
Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.
21.7K
Prokaryotic Transcriptional Activators and Repressors01:58

Prokaryotic Transcriptional Activators and Repressors

25.5K
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
25.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Why intrinsic reduced susceptibility in rare fungal pathogens should be differentiated from intrinsic resistance: an ISHAM conceptual framework and narrative review.

Antimicrobial agents and chemotherapy·2026
Same author

Early Signal Without Clinical Cases: A Single Clade III <i>Candidozyma auris</i> Isolate from a Face Mask Highlights the Value of Environmental Quality Control.

Journal of fungi (Basel, Switzerland)·2026
Same author

Can voriconazole gradient diffusion testing results be extrapolated to isavuconazole and posaconazole in <i>Aspergillus</i> spp.? Comparative analysis with CLSI broth microdilution and <i>cyp51A</i> gene sequencing.

Antimicrobial agents and chemotherapy·2026
Same author

An automated workflow for fungal cell counting, cell size and data analysis: enhancing throughput and accuracy with the cell analysis and counting tool using ilastik software (caactus).

BMC microbiology·2026
Same author

Six-month surveillance of <i>Candida parapsilosis</i> in Tyrol, Austria: high-risk ST11 lineage and early, heterogeneous fluconazole resistance.

Frontiers in cellular and infection microbiology·2026
Same author

Closing the gap on antifungal resistance.

Nature medicine·2026

Related Experiment Video

Updated: Feb 5, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K

Candida: Platelet Interaction and Platelet Activity in vitro.

Claudia Eberl1, Cornelia Speth2, Ilse D Jacobsen3,4

  • 1Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.

Journal of Innate Immunity
|September 4, 2018
PubMed
Summary

Platelets show limited interaction with Candida, a common fungal pathogen. This weak immune response may allow Candida to survive in the bloodstream, contributing to severe infections like sepsis.

Keywords:
Antimicrobial peptidesCandida sppInnate immunityInvasive candidiasisPlatelet activationPlatelets

More Related Videos

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.1K
Purification of Platelets from Mouse Blood
05:41

Purification of Platelets from Mouse Blood

Published on: May 7, 2019

23.7K

Related Experiment Videos

Last Updated: Feb 5, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.1K
Purification of Platelets from Mouse Blood
05:41

Purification of Platelets from Mouse Blood

Published on: May 7, 2019

23.7K

Area of Science:

  • Immunology
  • Mycology
  • Hematology

Background:

  • Platelets are increasingly recognized for their role in innate immunity.
  • Platelet interactions with fungal pathogens significantly impact invasive mycoses outcomes.
  • The specific role of platelets in Candida infections remains poorly understood and debated.

Purpose of the Study:

  • To investigate the interaction between human platelets and various forms of pathogenic Candida species.
  • To assess the impact of Candida on platelet activity and vice versa.
  • To elucidate the contribution of platelet function to the pathogenesis of Candida sepsis.

Main Methods:

  • Utilized platelet-rich plasma and a whole blood model to simulate in vivo conditions.
  • Studied interactions with Candida yeast cells, pseudohyphae, biofilms, and secretory products.
  • Analyzed platelet binding, activation, and effects on Candida growth and viability.

Main Results:

  • Observed moderate, species-variable interactions between platelets and Candida morphotypes.
  • Low platelet binding rates were noted for Candida hyphae and biofilms compared to yeast forms.
  • Candida secretory products did not influence platelet activity.
  • Activated platelets showed no significant reduction in Candida growth or viability.
  • Whole blood model confirmed activation in Candida-bound platelets.

Conclusions:

  • Platelets exhibit limited efficacy in combating Candida infections.
  • The observed weak platelet response to Candida may promote fungal survival in the bloodstream.
  • This platelet dysfunction could contribute to the high morbidity associated with Candida sepsis.