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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Pediatric Obstructive Sleep Apnea is Associated With Changes in the Oral Microbiome and Urinary Metabolomics Profile:

Huajun Xu1,2,3, Xiaoyan Li4, Xiaojiao Zheng5

  • 1Department of Otolaryngology Head and Neck Surgery and Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
|September 5, 2018
PubMed

Insights

Pediatric obstructive sleep apnea (OSA) alters oral microbiome composition and urinary metabolites. These changes in oral bacteria correlate with metabolic disruptions, suggesting a link between gut and oral health in children with OSA.

Area of Science:

  • Microbiology
  • Metabolomics
  • Pediatric Health

Background:

  • Oral diseases are linked to obstructive sleep apnea (OSA).
  • Limited research exists on oral microbiota and metabolic profiles in pediatric OSA.

Purpose of the Study:

  • To investigate oral microbiome structure and composition in pediatric OSA.
  • To evaluate associations between oral microbiota and urinary metabolic profiles in pediatric OSA.

Main Methods:

  • Integrated metagenomics (16S rRNA sequencing) and metabolomics (LC-MS, GC-MS).
  • Analysis of oral microbiome and urinary metabolome in pediatric OSA patients and controls.

Main Results:

  • Pediatric OSA significantly altered oral microbiome composition (e.g., Firmicutes, Proteobacteria).
  • 57 urinary metabolites, including 5 gut microflora-related, were differentially present in pediatric OSA.
  • Oral microbiome alterations correlated with urinary metabolite perturbations in pediatric OSA.

Conclusions:

  • Oral microbiome composition and function are significantly altered in pediatric OSA.
  • Further research is needed to elucidate the underlying mechanisms.
Abstract

Keywords:
metabolomicsmetagenomicsobstructive sleep apneaoral microbiota

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