Related Experiment Video
Updated: Feb 5, 2026
07:00
A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
10.4K
Effects of Klotho polymorphisms on Preeclampsia risk in a case-control study
Jingli Wang1, Yan Lin2, Fuyan Lv3
1Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
Pregnancy Hypertension
|September 5, 2018
Summary
This study found no significant association between Klotho gene polymorphisms (rs1207568 and rs564481) and preeclampsia (PE) susceptibility in Chinese Han women, suggesting these variants are not key factors in PE development.
Area of Science:
- Genetics
- Obstetrics
- Molecular Biology
Background:
- Preeclampsia (PE) is a severe pregnancy disorder impacting maternal and fetal health, often linked to oxidative stress and genetic factors.
- The Klotho gene encodes a protein that enhances resistance to oxidative stress, making it a potential candidate in PE research.
Purpose of the Study:
- To investigate the association between Klotho gene polymorphisms (rs1207568 and rs564481) and the susceptibility to preeclampsia in Chinese Han women.
Main Methods:
- A case-control study genotyped two Klotho SNPs (rs1207568 and rs564481) in 1002 PE patients and 1384 controls using TaqMan allelic discrimination real-time PCR.
- Subgroup analyses were performed for mild vs. severe and early-onset vs. late-onset PE.
Main Results:
- No significant differences in genotypic or allelic frequencies were observed for either SNP between PE patients and controls.
- Subgroup analyses also revealed no significant associations for either SNP in relation to PE severity or onset.
Conclusions:
- The investigated Klotho gene variants (rs1207568 and rs564481) do not appear to play a significant role in the pathogenesis of preeclampsia among Chinese Han women.
More Related Videos
Related Concept Videos
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
474
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
474
01:12Relative Risk
2.2K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K
01:05Single Nucleotide Polymorphisms-SNPs
18.4K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.4K
01:26Factors Affecting the Risk of Infection
13.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.6K
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
734
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
734
02:19Buffer Effectiveness
55.4K
Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
The buffer capacity is the amount of acid or base that can be added to a given volume...
55.4K